FIGURE

Figure 4

ID

ZDB-FIG-230502-4

Publication

Kondo et al., 2023 - The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney

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Figure 4

Loss of Jam1a reduces long-term hematopoietic reconstitution activity

(A and B) Representative result of FCM analysis in KMCs from wild-type or jam1a^sd43 animals under a gata2a:GFP; runx1:mCherry background.

(C) Absolute numbers of gata2a⁺runx1⁺ cells in the wild-type or jam1a^sd43 kidney (mean ± s.e.m; n = 16 [wild-type] or 13 [jam1a^sd43]).

(D) Experimental procedure for competitive repopulation assay using gata2a⁺runx1⁺ cells.

(E) Percentages of BFP⁺ cells within total BFP⁺ or dsRed⁺ cells in each group (mean ± s.e.m; n = 9 [wild-type] or 6 [jam1a^sd43]). ∗p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f11r.1^sd43/sd43; s898Tg; sd27Tg
Observed In:	kidney regulation of hematopoietic progenitor cell differentiation
Stage:	Adult

Phenotype Detail

Acknowledgments

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