FIGURE

Fig. 6

ID

ZDB-FIG-200903-7

Publication

Schumacher et al., 2020 - Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis

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Fig. 6

Fig. 6. Expression of endocardial genes is reduced or absent in itga4;itga5 double mutants at later stages. (A–C) nfatc1 expression is reduced or absent in the endocardium of itga4;itga5 double mutants compared to siblings and WT at 48 hpf. (D–F) notch1b expression in the AV canal endocardium is absent in itga4;itga5 double mutants compared to siblings and WT at 48 hpf. (G–I) klf2a expression in the AV canal endocardium is absent in itga4;itga5 double mutants compared to siblings and WT at 52 hpf. Frontal views, arrowheads indicate AV canal region of the endocardium.

Expression Data

Genes:	klf2a nfatc1 notch1b
Fish:	WT itga4^{sa14884/sa14884}; itga5^tbfe1/tbfe1
Anatomical Terms:	atrioventricular canal atrium cardiac ventricle endocardium
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	itga4^{sa14884/sa14884}; itga5^tbfe1/tbfe1
Observed In:	atrioventricular canal endocardial cell differentiation endocardium
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 465(1), Schumacher, J.A., Wright, Z.A., Owen, M., Bredemeier, N.O., Sumanas, S., Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis, 46-57, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.