Gene

nfatc1

ID
ZDB-GENE-060503-677
Name
nuclear factor of activated T cells 1
Symbol
nfatc1 Nomenclature History
Previous Names
  • si:ch211-198c22.2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a negative effect on lymphangiogenesis. Acts upstream of or within atrioventricular valve morphogenesis and response to mechanical stimulus. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; bone tissue; heart; olfactory system; and scale. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
29 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
bns276Allele with one deletionUnknownUnknownCRISPR
la020672TgTransgenic insertionUnknownUnknownDNA
sa36826Allele with one point mutationUnknownPremature StopENU
sa39244Allele with one point mutationUnknownPremature StopENU
um264Allele with one deletionUnknownFrameshift, Premature StopCRISPR
y617Allele with one deletionUnknownFrameshift, Premature StopCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With nfatc1 Human Ortholog
No data available
Associated With nfatc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002909 IPT domain
Domain IPR011539 Rel homology domain, DNA-binding domain
Domain IPR032397 Rel homology dimerisation domain
Family IPR008366 Nuclear factor of activated T cells (NFAT)
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain Nuclear factor of activated T cells (NFAT) p53-like transcription factor, DNA-binding domain superfamily Rel homology dimerisation domain Rel homology domain, DNA-binding domain Rel homology domain (RHD), DNA-binding domain superfamily
UniProtKB:Q19AW4 InterPro 867
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nfatc1-201 (1) Ensembl 3,905 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(nfatc1:GAL4FF)
  • nfatc1
  • Danio rerio
1 (10)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-196L6ZFIN Curated Data
Contained inBACCH73-309F6ZFIN Curated Data
Contained inBACCH211-198C22ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanNFATC118
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseNfatc118
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Citations
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