Gene
nfatc1
- ID
- ZDB-GENE-060503-677
- Name
- nuclear factor of activated T cells 1
- Symbol
- nfatc1 Nomenclature History
- Previous Names
-
- si:ch211-198c22.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a negative effect on lymphangiogenesis. Acts upstream of or within atrioventricular valve morphogenesis and response to mechanical stimulus. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; bone tissue; heart; olfactory system; and scale. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
bns276 | Allele with one deletion | Unknown | Unknown | CRISPR | |
la020672Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa36826 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa39244 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
um264 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
y617 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-nfatc1 | Jung et al., 2019 | |
CRISPR2-nfatc1 | Shin et al., 2019 | |
CRISPR3-nfatc1 | Gunawan et al., 2020 | |
CRISPR4-nfatc1 | Bu et al., 2021 | |
MO1-nfatc1 | N/A | (2) |
MO2-nfatc1 | N/A | Jung et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR002909 | IPT domain |
Domain | IPR011539 | Rel homology domain, DNA-binding domain |
Domain | IPR032397 | Rel homology dimerisation domain |
Family | IPR008366 | Nuclear factor of activated T cells (NFAT) |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Nuclear factor of activated T cells (NFAT) | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q19AW4 | InterPro | 867 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
nfatc1-201
(1)
|
Ensembl | 3,905 nt |
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Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC(nfatc1:GAL4FF) |
|
| 1 | (10) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-196L6 | ZFIN Curated Data | |
Contained in | BAC | CH73-309F6 | ZFIN Curated Data | |
Contained in | BAC | CH211-198C22 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045159 (1) | 2991 nt | ||
Genomic | GenBank:BX855612 (1) | 212866 nt | ||
Polypeptide | UniProtKB:Q19AW4 (1) | 867 aa |
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Zhong, Y.T., Liao, H.B., Ye, Z.Q., Jiang, H.S., Li, J.X., Ke, L.M., Hua, J.Y., Wei, B., Wu, X., Cui, L. (2023) Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling. Journal of orthopaedic translation. 40:132146132-146
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Gurung, S., Restrepo, N.K., Chestnut, B., Klimkaite, L., Sumanas, S. (2022) Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos. Scientific Reports. 12:13065
- Halabi, R., Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2022) Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development. Cell communication and signaling : CCS. 20:126
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
- Molagoda, I.M.N., Athapaththu, A.M.G.K., Park, E.K., Choi, Y.H., Jeon, Y.J., Kim, G.Y. (2022) Fermented Oyster (Crassostrea gigas) Extract Cures and Prevents Prednisolone-Induced Bone Resorption by Activating Osteoblast Differentiation. Foods (Basel, Switzerland). 11(5):
- Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
- Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
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