Fig. 5
- ID
- ZDB-FIG-140325-16
- Publication
- Wang et al., 2014 - Notch3 establishes brain vascular integrity by regulating pericyte number
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Notch3 is required for brain pericyte proliferation. (A-C) N3ECD-GFP overexpression results in fewer pdgfrb+ brain pericytes at 72 hpf. (A) Non-transgenic control fish. (B,C) Tg(hsp70I:N3ECD-GFP) larvae heat-shocked at 30 hpf and 48 hpf. Arrowheads, pdgfrb+ brain pericytes. (D) Quantification of pdgfrb+ brain pericytes in control and Tg(hsp70I:N3ECD-GFP) larvae at 72 hpf (ne31 each). (E) Quantification of brain pericytes and percentage of EdU+ pericytes in control and Tg(hsp70I:N3ECD-GFP) larvae heat-shocked at 72 hpf and EdU pulsed at 78 hpf (n=42 each). Error bars represent s.d. *P<0.001 by Student’s two-tailed t-test. Scale bar: 200 μm. |
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Stage: | Protruding-mouth |
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Stage: | Protruding-mouth |