FIGURE

Fig. 5

ID

ZDB-FIG-140325-16

Publication

Wang et al., 2014 - Notch3 establishes brain vascular integrity by regulating pericyte number

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Fig. 5

Notch3 is required for brain pericyte proliferation. (A-C) N3ECD-GFP overexpression results in fewer pdgfrb⁺ brain pericytes at 72 hpf. (A) Non-transgenic control fish. (B,C) Tg(hsp70I:N3ECD-GFP) larvae heat-shocked at 30 hpf and 48 hpf. Arrowheads, pdgfrb⁺ brain pericytes. (D) Quantification of pdgfrb⁺ brain pericytes in control and Tg(hsp70I:N3ECD-GFP) larvae at 72 hpf (ne31 each). (E) Quantification of brain pericytes and percentage of EdU⁺ pericytes in control and Tg(hsp70I:N3ECD-GFP) larvae heat-shocked at 72 hpf and EdU pulsed at 78 hpf (n=42 each). Error bars represent s.d. ^*P<0.001 by Student’s two-tailed t-test. Scale bar: 200 μm.

Expression Data

Genes:	EGFP pdgfrb
Fish:	co15Tg; y1Tg
Condition:	heat shock
Anatomical Terms:	cranial blood vessel cranial blood vessel pericyte
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	co15Tg; y1Tg
Condition:	heat shock
Observed In:	cranial blood vessel pericyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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