FIGURE

Fig. 5

ID

ZDB-FIG-101007-45

Publication

Imai et al., 2010 - The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish

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Fig. 5

Polyubiquitylated proteins are localized in lens fiber cell nuclei. (A-F) Labeling of wild-type (A-C) and vov mutant (D-F) zebrafish lens of the indicated stages with anti-polyubiquitylated protein antibody (FK2, green) and TOPRO3 (red). Arrowheads indicate signals in nuclei of differentiating lens fiber cells at 72 hpf (C). Scanning conditions of images in D,F were the same as those for B,C. (E) The same image as D but with reduced sensitivity of fluorescence detection. (A′-F′,A"-F") The same images as A-F but shown through a green (FK2) or red (TOPRO3) channel. Scale bars: 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	psmd6^rw619/rw619
Observed In:	lens nucleus proteasome-mediated ubiquitin-dependent protein catabolic process
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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