FIGURE

Fig. 3

ID

ZDB-FIG-091214-11

Publication

Bonkowsky et al., 2008 - Domain-specific regulation of foxP2 CNS expression by lef1

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Fig. 3

Loss of lef1 leads to absent foxP2 expression in the tectum, mid-hindbrain boundary, and hindbrain. Whole-mount in situs at 36 hpf; anterior to left, dorsal up, eyes removed. Scale bar = 50 μm. (Conditions: hs:Δtcf, Tg(hsp70l:Δtcf-GFP)^w26; lef1 mo, lef1 morphants; wt, wild type; x8, homozygous Df(LG01)^x8. Abbreviations: hb, hindbrain; mhb, mid-hindbrain boundary; tec, tectum; tel, telencephalon.) (A, B) lef1 morphant (B) lacks expression in tectum, MHB, and hindbrain (arrows), compared to wild-type (A). (C) Df(LG01)^x8homozygote lacks expression in tectum, MHB, and hindbrain (arrows). (D) Tg(hsp70l:Δtcf:GFP)^w26embryo, three hours post-heat shock, lacks expression in tectum, MHB, and hindbrain (arrows). (E, F) mbx in situs; staining in tectum and hindbrain is indistinguishable between wild type and lef1 morphants (F).

Expression Data

Genes:	dmbx1a foxp2
Fish:	WT WT + MO2-lef1 w26Tg Df(Chr01:lef1,msxb)x8/x8
Condition:	heat shock
Knockdown Reagent:	MO2-lef1
Anatomical Terms:	hindbrain midbrain hindbrain boundary optic tectum telencephalon
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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