ZFIN Morpholino: MO2-lef1

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-lef1

No data available

Phenotype

Phenotype resulting from MO2-lef1

Phenotype	Fish	Figures
brain wholly posteriorized, abnormal	WT + MO2-lef1	Fig. 6 from Nyholm et al., 2007
cartilage morphogenesis disrupted, abnormal	WT + MO2-lef1	Fig. 1 from Ishitani et al., 2005
cell proliferation in midbrain decreased occurrence, abnormal	WT + MO2-lef1	Fig. 2 from Ota et al., 2012
cranial cartilage morphology, abnormal	WT + MO2-lef1	Fig. 1 from Ishitani et al., 2005
diencephalon dopaminergic neuron increased amount, abnormal	WT + MO2-lef1	Fig. 8 , Fig. S6 from Russek-Blum et al., 2008

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Phenotype of all Fish created by or utilizing MO2-lef1

Phenotype	Fish	Conditions	Figures
brain wholly posteriorized, abnormal	WT + MO2-lef1	standard conditions	Fig. 6 from Nyholm et al., 2007
dorsal root ganglion decreased amount, abnormal	WT + MO2-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005
dorsal root ganglion mislocalised, abnormal	WT + MO2-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005
neural crest cell development disrupted, abnormal	WT + MO2-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005
cranial cartilage morphology, abnormal	WT + MO2-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005

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Citations

Include unpublished citations

Zhu, P., Xu, X., Lin, X. (2015) Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biology Open. 4(11):1376-86
Ota, S., Ishitani, S., Shimizu, N., Matsumoto, K., Itoh, M., and Ishitani, T. (2012) NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells. The EMBO journal. 31(8):1904-1915
Rai, K., Jafri, I.F., Chidester, S., James, S.R., Karpf, A.R., Cairns, B.R., and Jones, D.A. (2010) Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. The Journal of biological chemistry. 285(6):4110-4121
Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942
Danesin, C., Peres, J.N., Johansson, M., Snowden, V., Cording, A., Papalopulu, N., and Houart, C. (2009) Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1. Developmental Cell. 16(4):576-587
Bonkowsky, J.L., Wang, X., Fujimoto, E., Lee, J.E., Chien, C.B., and Dorsky, R.I. (2008) Domain-specific regulation of foxP2 CNS expression by lef1. BMC Developmental Biology. 8:103
Russek-Blum, N., Gutnick, A., Nabel-Rosen, H., Blechman, J., Staudt, N., Dorsky, R.I., Houart, C., and Levkowitz, G. (2008) Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development (Cambridge, England). 135(20):3401-3413
Nyholm, M.K., Wu, S.F., Dorsky, R.I., and Grinblat, Y. (2007) The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum. Development (Cambridge, England). 134(4):735-746
Lee, J.E., Wu, S.F., Goering, L.M., and Dorsky, R.I. (2006) Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development (Cambridge, England). 133(22):4451-4461
Ishitani, T., Matsumoto, K., Chitnis, A.B., and Itoh, M. (2005) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nature cell biology. 7(11):1106-1112

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