PUBLICATION
Gonacin: A germ cell-derived hormone with glucogenic, orexigenic, and gonadal activities
- Authors
- Hu, Y., Zhao, S., Liu, Z., Kang, T., Hsueh, A.J.W., Li, J.
- ID
- ZDB-PUB-231020-61
- Date
- 2023
- Source
- iScience 26: 108065108065 (Journal)
- Registered Authors
- Keywords
- Biological sciences, Endocrinology, Female reproductive endocrinology, Male reproductive endocrinology, Natural sciences
- MeSH Terms
- none
- PubMed
- 37860761 Full text @ iScience
Citation
Hu, Y., Zhao, S., Liu, Z., Kang, T., Hsueh, A.J.W., Li, J. (2023) Gonacin: A germ cell-derived hormone with glucogenic, orexigenic, and gonadal activities. iScience. 26:108065108065.
Abstract
Fish require abundant nutrients to generate a large number of eggs for spawning. Based on the evolutionary conservation of human FBN2 and its C-terminal placensin-like sequences in fish, we identified a peptide hormone gonacin (GONAdal Cell placensIN) and found its high expression in early-stage germ cells in the ovary and testis of zebrafish. We demonstrated that gonacin is essential for food intake, glucose release, and ovarian development in zebrafish. Similar expression patterns and functions of gonacin were also demonstrated in rainbow trout. Gonacin represents the first hormone secreted by germ cells with endocrine functions in vertebrates, bridging the energy homeostasis and reproduction.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping