PUBLICATION

Kappe neurons, a novel population of olfactory sensory neurons

Authors
Ahuja, G., Nia, S.B., Zapilko, V., Shiriagin, V., Kowatschew, D., and Oka, Y., and Korsching, S.I.
ID
ZDB-PUB-140416-5
Date
2014
Source
Scientific Reports   4: 4037 (Journal)
Registered Authors
Ahuja, Gaurav, Korsching, Sigrun, Zapilko, Veronika
Keywords
none
MeSH Terms
  • Staining and Labeling
  • Zebrafish/anatomy & histology*
  • Zebrafish/physiology
  • Olfactory Perception*
  • Animals
  • Tubulin/immunology
  • Immunohistochemistry
  • Actins/immunology
  • Smell
  • Antibodies/immunology
  • Olfactory Bulb/physiology*
  • Olfactory Receptor Neurons/immunology
  • Olfactory Receptor Neurons/physiology*
(all 13)
PubMed
24509431 Full text @ Sci. Rep.
Abstract

Perception of olfactory stimuli is mediated by distinct populations of olfactory sensory neurons, each with a characteristic set of morphological as well as functional parameters. Beyond two large populations of ciliated and microvillous neurons, a third population, crypt neurons, has been identified in teleost and cartilaginous fishes. We report here a novel, fourth olfactory sensory neuron population in zebrafish, which we named kappe neurons for their characteristic shape. Kappe neurons are identified by their Go-like immunoreactivity, and show a distinct spatial distribution within the olfactory epithelium, similar to, but significantly different from that of crypt neurons. Furthermore, kappe neurons project to a single identified target glomerulus within the olfactory bulb, mdg5 of the mediodorsal cluster, whereas crypt neurons are known to project exclusively to the mdg2 glomerulus. Kappe neurons are negative for established markers of ciliated, microvillous and crypt neurons, but appear to have microvilli. Kappe neurons constitute the fourth type of olfactory sensory neurons reported in teleost fishes and their existence suggests that encoding of olfactory stimuli may require a higher complexity than hitherto assumed already in the peripheral olfactory system.

Genes / Markers
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
rw035TgTransgenic Insertion
    rw036TgTransgenic Insertion
      1 - 2 of 2
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
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      Antibodies
      Name Type Antigen Genes Isotypes Host Organism
      Ab1-gnao1polyclonal
        IgGRabbit
        Ab1-ntrk1polyclonal
          IgGRabbit
          Ab1-s100polyclonalRabbit
          Ab4-calb2monoclonal
            Mouse
            zns-2monoclonal
              IgG1Mouse
              1 - 5 of 5
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              Orthology
              No data available
              Engineered Foreign Genes
              Marker Marker Type Name
              mRFPEFGmRFP
              RFPEFGRFP
              VenusEFGVenus
              1 - 3 of 3
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              Mapping
              No data available