Gene
trpc2b
- ID
- ZDB-GENE-050712-3
- Name
- transient receptor potential cation channel subfamily C member 2b
- Symbol
- trpc2b Nomenclature History
- Previous Names
-
- trpc2
- trpc2a (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in microvillous olfactory receptor neurons; olfactory epithelium; olfactory receptor cell; and olfactory rosette. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23977 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013555 | Transient receptor ion channel domain |
| Family | IPR002153 | Transient receptor potential channel, canonical |
| Family | IPR005458 | Transient receptor potential channel, canonical 2 |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical | Transient receptor potential channel, canonical 2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q4VDB0 | InterPro | 1140 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trpc2b-201
(1)
|
Ensembl | 3,555 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4.5trpc2b:GAP-GFP) |
|
| 1 | (4) | |
| Tg(-4.5trpc2b:GAP-Venus) |
|
| 1 | (23) | |
| Tg(-9.0trpc2b:GAP-Venus) |
|
| 1 | (9) | |
| Tg(trpc2b:GAL4) |
|
| 1 | (6) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-22F5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194340 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030166 (1) | 3558 nt | ||
| Genomic | GenBank:BX511168 (1) | 245435 nt | ||
| Polypeptide | UniProtKB:Q4VDB0 (1) | 1140 aa |
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Zhu, H., Zhang, X., Xu, S., Wu, J., Hou, M., Zhao, H., Zhou, Q., Zhong, X. (2022) Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 338(5):301-313
- Volz, S.N., Hausen, J., Nachev, M., Ottermanns, R., Schiwy, S., Hollert, H. (2020) Short exposure to cadmium disrupts the olfactory system of zebrafish (Danio rerio) - Relating altered gene expression in the olfactory organ to behavioral deficits. Aquatic toxicology (Amsterdam, Netherlands). 226:105555
- Messina, A., Pulli, K., Santini, S., Acierno, J., Känsäkoski, J., Cassatella, D., Xu, C., Casoni, F., Malone, S.A., Ternier, G., Conte, D., Sidis, Y., Tommiska, J., Vaaralahti, K., Dwyer, A., Gothilf, Y., Merlo, G.R., Santoni, F., Niederländer, N.J., Giacobini, P., Raivio, T., Pitteloud, N. (2019) Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. American journal of human genetics. 106(1):58-70
- Aguillon, R., Batut, J., Subramanian, A., Madelaine, R., Dufourcq, P., Schilling, T.F., Blader, P. (2018) Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm. eLIFE. 7
- Ahuja, G., Reichel, V., Kowatschew, D., Syed, A.S., Kotagiri, A.K., Oka, Y., Weth, F., Korsching, S.I. (2018) Overlapping but distinct topology for zebrafish V2R-like olfactory receptors reminiscent of odorant receptor spatial expression zones. BMC Genomics. 19:383
- Bayramli, X., Kocagöz, Y., Sakizli, U., Fuss, S.H. (2017) Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons. Scientific Reports. 7:5572
- Lindström, J.B., Pierce, N.T., Latz, M.I. (2017) Role of TRP Channels in Dinoflagellate Mechanotransduction. The Biological bulletin. 233:151-167
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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