PUBLICATION

Movement Directionality in Collective Migration of Germ Layer Progenitors

Authors
Arboleda-Estudillo, Y., Krieg, M., Stühmer, J., Licata, N.A., Muller, D.J., and Heisenberg, C.P.
ID
ZDB-PUB-100119-17
Date
2010
Source
Current biology : CB   20(2): 161-169 (Journal)
Registered Authors
Heisenberg, Carl-Philipp
Keywords
CELLBIO, DEVBIO
MeSH Terms
  • Cell Adhesion
  • Microscopy, Confocal
  • Germ Cells/cytology*
  • Cell Movement*
  • Animals
  • DNA Primers
  • Base Sequence
  • Zebrafish
(all 8)
PubMed
20079641 Full text @ Curr. Biol.
Abstract
Collective cell migration, the simultaneous movement of multiple cells that are connected by cell-cell adhesion, is ubiquitous in development, tissue repair, and tumor metastasis [1, 2]. It has been hypothesized that the directionality of cell movement during collective migration emerges as a collective property [3, 4]. Here we determine how movement directionality is established in collective mesendoderm migration during zebrafish gastrulation. By interfering with two key features of collective migration, (1) having neighboring cells and (2) adhering to them, we show that individual mesendoderm cells are capable of normal directed migration when moving as single cells but require cell-cell adhesion to participate in coordinated and directed migration when moving as part of a group. We conclude that movement directionality is not a de novo collective property of mesendoderm cells but rather a property of single mesendoderm cells that requires cell-cell adhesion during collective migration.
Genes / Markers
Figures
Figure Gallery (5 images)
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Expression
No data available
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
tdgf1_unspecified
    Unspecified
    tx230
      Point Mutation
      1 - 2 of 2
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      Target Reagent Reagent Type
      cdh1MO3-cdh1MRPHLNO
      1 - 1 of 1
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      Fish
      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available