PUBLICATION
Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos
- Authors
- Kim, H., Shin, J., Kim, S., Poling, J., Park, H.C., and Appel, B.
- ID
- ZDB-PUB-080722-10
- Date
- 2008
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 237(8): 2081-2089 (Journal)
- Registered Authors
- Appel, Bruce, Park, Hae-Chul, Shin, Jimann
- Keywords
- spinal cord, oligodendrocyte, motor neuron, radial glia, zebrafish transgenic, Notch
- MeSH Terms
-
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism*
- Cell Lineage/physiology
- Animals
- Signal Transduction/physiology
- PubMed
- 18627107 Full text @ Dev. Dyn.
Abstract
During vertebrate neural development, many dividing neuroepithelial precursors adopt features of radial glia, which are now known to also serve as neural precursors. In mammals, most radial glia do not persist past early postnatal stages, whereas zebrafish maintain large numbers of radial glia into adulthood. The mechanisms that maintain and specify radial glia for different fates are still poorly understood. We investigated formation of radial glia in the spinal cord of zebrafish and the role of Notch signaling in their maintenance and specification. We found that spinal cord precursors begin to express gfap(+), a marker of radial glia, during neurogenesis and that gfap cells give rise to both neurons and oligodendrocytes. We also determined that Notch signaling is continuously required during embryogenesis to maintain radial glia, limit motor neuron formation and permit oligodendrocyte development, but that radial glia seem to be refractory to changes in Notch activity in postembryonic animals.
Genes / Markers
Figure Gallery (6 images)
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping