ZFIN Morpholino: MO1-aggf1

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-aggf1

No data available

Phenotype

Phenotype resulting from MO1-aggf1

Phenotype	Fish	Figures
angioblast cell differentiation process quality, abnormal	AB + MO1-aggf1	Fig. 3 from Li et al., 2014
angioblastic mesenchymal cell tal1 expression decreased amount, abnormal	WT + MO1-aggf1	Fig. 7 from Wang et al., 2017
caudal vein absent, abnormal	y1Tg + MO1-aggf1	Fig. 4 from Kashiwada et al., 2015
caudal vein malformed, abnormal	y1Tg + MO1-aggf1	Fig. 4 from Kashiwada et al., 2015
caudal vein plexus apoptotic process increased process quality, abnormal	ncv13Tg; ubs4Tg + MO1-aggf1	Fig. 4 from Kashiwada et al., 2015

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Phenotype of all Fish created by or utilizing MO1-aggf1

Phenotype	Fish	Conditions	Figures
hemangioblast cell differentiation process quality, abnormal	AB + MO1-aggf1	control	Fig. 3 from Li et al., 2014
nucleate erythrocyte decreased amount, abnormal	AB + MO1-aggf1	control	Fig. 1 from Li et al., 2014
definitive hemopoiesis process quality, abnormal	AB + MO1-aggf1	control	Fig. 2 from Li et al., 2014
lymphangioblast cord cell decreased amount, abnormal	AB + MO1-aggf1	standard conditions	Fig. 4 from Chen et al., 2013
primitive hemopoiesis process quality, abnormal	AB + MO1-aggf1	control	Fig. 1 from Li et al., 2014

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Citations

Include unpublished citations

Yang, Z., Guo, D., Zhao, J., Li, J., Zhang, R., Zhang, Y., Xu, C., Ke, T., Wang, Q.K. (2023) Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(12):2348-2368
Wang, L., Wang, X., Wang, L., Yousaf, M., Li, J., Zuo, M., Yang, Z., Gou, D., Bao, B., Li, L., Xiang, N., Jia, H., Xu, C., Chen, Q., Wang, Q.K. (2017) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1):183-194
Kashiwada, T., Fukuhara, S., Terai, K., Tanaka, T., Wakayama, Y., Ando, K., Nakajima, H., Fukui, H., Yuge, S., Saito, Y., Gemma, A., Mochizuki, N. (2015) β-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels. Development (Cambridge, England). 142(3):497-509
Li, L., Chen, D., Li, J., Wang, X., Wang, N., Xu, C., and Wang, Q.K. (2014) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood. 123(4):501-8
Chen, D., Li, L., Tu, X., Yin, Z., and Wang, Q. (2013) Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation during embryogenesis. Human molecular genetics. 22(5):963-976

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