Gene
aggf1
- ID
- ZDB-GENE-060929-836
- Name
- angiogenic factor with G patch and FHA domains 1
- Symbol
- aggf1 Nomenclature History
- Previous Names
-
- im:7146636
- zgc:152959
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable nucleic acid binding activity. Acts upstream of or within blood vessel development; hemangioblast cell differentiation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Is expressed in several structures, including blastomere; brain; cardiovascular system; head; and liver. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aggf1 | Yang et al., 2023 | |
| CRISPR2-aggf1 | Lv et al., 2025 | |
| MO1-aggf1 | N/A | (5) |
| MO2-aggf1 | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGGF1, OCRE domain | Angiogenic factor with G patch and FHA domains 1 | Forkhead-associated (FHA) domain | G-patch domain | OCRE domain | SMAD/FHA domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08CK9 | InterPro | 774 | ||||||
| UniProtKB:A0A8M9PIC1 | InterPro | 782 | ||||||
| UniProtKB:A0A8M9PTY3 | InterPro | 648 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | IMAGE:7146636 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:152959 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192793 | ZFIN Curated Data |
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- Lv, W., Zhang, J., Lyu, D., Zhang, R., Xu, C., Ning, K., Li, M., Zhao, Y., Han, J., Wang, Q.K. (2025) Angiogenic factor AGGF1 is a general splicing factor regulating angiogenesis and vascular development by alternative splicing of SRSF6. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70443e70443
- Yang, Z., Guo, D., Zhao, J., Li, J., Zhang, R., Zhang, Y., Xu, C., Ke, T., Wang, Q.K. (2023) Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(12):2348-2368
- Zhang, C., Zhang, Q., Wang, J., Tian, J., Song, Y., Xie, H., Chang, M., Nie, P., Gao, Q., Zou, J. (2019) Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish & shellfish immunology. 94:685-696
- Wang, L., Wang, X., Wang, L., Yousaf, M., Li, J., Zuo, M., Yang, Z., Gou, D., Bao, B., Li, L., Xiang, N., Jia, H., Xu, C., Chen, Q., Wang, Q.K. (2017) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1):183-194
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kashiwada, T., Fukuhara, S., Terai, K., Tanaka, T., Wakayama, Y., Ando, K., Nakajima, H., Fukui, H., Yuge, S., Saito, Y., Gemma, A., Mochizuki, N. (2015) β-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels. Development (Cambridge, England). 142(3):497-509
- Li, L., Chen, D., Li, J., Wang, X., Wang, N., Xu, C., and Wang, Q.K. (2014) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood. 123(4):501-8
- Chen, D., Li, L., Tu, X., Yin, Z., and Wang, Q. (2013) Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation during embryogenesis. Human molecular genetics. 22(5):963-976
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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