ZFIN Morpholino: MO3-sox3

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-sox3

No data available

Phenotype

Phenotype resulting from MO3-sox3

Phenotype	Fish	Figures
epibranchial ganglion decreased amount, abnormal	AB + MO3-sox3	Fig. 2 from Padanad et al., 2011
otic placode pax2a expression decreased amount, abnormal	AB + MO3-sox3 + MO4-tp53	Fig. 7 from Gou et al., 2018
otic placode pax2a expression decreased distribution, abnormal	AB + MO3-sox3 + MO4-tp53	Fig. 7 from Gou et al., 2018

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Phenotype of all Fish created by or utilizing MO3-sox3

Phenotype	Fish	Conditions	Figures
epibranchial ganglion decreased amount, abnormal	AB + MO3-sox3	standard conditions	Fig. 2 from Padanad et al., 2011
otic placode pax2a expression decreased amount, abnormal	AB + MO3-sox3 + MO4-tp53	standard conditions	Fig. 7 from Gou et al., 2018
otic placode pax2a expression decreased distribution, abnormal	AB + MO3-sox3 + MO4-tp53	standard conditions	Fig. 7 from Gou et al., 2018
ectoderm pax8 expression mislocalised, abnormal	x17Tg/+ + MO3-sox3 + MO4-tp53 (AB)	heat shock	Fig. 10 from Gou et al., 2018
otic placode pax8 expression increased distribution, abnormal	x17Tg/+ + MO3-sox3 + MO4-tp53 (AB)	heat shock	Fig. 10 from Gou et al., 2018

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Citations

Include unpublished citations

Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
Gou, Y., Guo, J., Maulding, K., Riley, B.B. (2018) sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish. Developmental Biology. 435(1):84-95
Hagey, D.W., Zaouter, C., Combeau, G., Andersson Lendahl, M., Andersson, O., Huss, M., Muhr, J. (2016) Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells. Genome research. 26(7):908-17
Lee, M.T., Bonneau, A.R., Takacs, C.M., Bazzini, A.A., Divito, K.R., Fleming, E.S., and Giraldez, A.J. (2013) Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature. 503(7476):360-4
Leichsenring, M., Maes, J., Mössner, R., Driever, W., and Onichtchouk, D. (2013) Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science (New York, N.Y.). 341(6149):1005-1009
Padanad, M.S., and Riley, B.B. (2011) Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24. Developmental Biology. 351(1):90-98
Okuda, Y., Ogura, E., Kondoh, H., and Kamachi, Y. (2010) B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo. PLoS Genetics. 6:e1000936

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