ZFIN Morpholino: MO1-sox18

Target Location

Genome Build: GRCz11Chromosome: 23

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-sox18

No data available

Phenotype

Phenotype resulting from MO1-sox18

Phenotype	Fish	Figures
artery blood vessel endothelium EGFP expression decreased amount, abnormal	zf2188Tg + MO1-sox18	Fig. 7 from Chiang et al., 2017
dorsal aorta EGFP expression decreased amount, abnormal	zf2188Tg + MO1-sox18	Fig. 7 from Chiang et al., 2017
dorsal aorta blood vessel endothelium EGFP expression decreased amount, abnormal	s843Tg; um13Tg + MO1-sox18	Fig. 5 from Duong et al., 2014
intersegmental vessel EGFP expression decreased amount, abnormal	zf2188Tg + MO1-sox18	Fig. 7 from Chiang et al., 2017
posterior cardinal vein blood vessel endothelium EGFP expression decreased amount, abnormal	s843Tg; um13Tg + MO1-sox18	Fig. 5 from Duong et al., 2014

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Phenotype of all Fish created by or utilizing MO1-sox18

Phenotype	Fish	Conditions	Figures
artery blood vessel endothelium EGFP expression decreased amount, abnormal	zf2188Tg + MO1-sox18	standard conditions	Fig. 7 from Chiang et al., 2017
dorsal aorta EGFP expression decreased amount, abnormal	zf2188Tg + MO1-sox18	standard conditions	Fig. 7 from Chiang et al., 2017
intersegmental vessel EGFP expression decreased amount, abnormal	zf2188Tg + MO1-sox18	standard conditions	Fig. 7 from Chiang et al., 2017
dorsal aorta blood vessel development process quality, abnormal	s843Tg; um13Tg + MO1-sox18	chemical treatment by environment: 2-(2-amino-3-methoxyphenyl)chromen-4-one	Fig. 6 from Duong et al., 2014
dorsal aorta blood vessel endothelium EGFP expression decreased amount, abnormal	s843Tg; um13Tg + MO1-sox18	standard conditions	Fig. 5 from Duong et al., 2014

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Citations

Include unpublished citations

Arnold, H., Panara, V., Hußmann, M., Filipek-Gorniok, B., Skoczylas, R., Ranefall, P., Gloger, M., Allalou, A., Hogan, B.M., Schulte-Merker, S., Koltowska, K. (2022) mafba and mafbb differentially regulate lymphatic endothelial cell migration in topographically distinct manners. Cell Reports. 39:110982
Chiang, I.K., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Hermkens, D., Lesieur, E., Liu, K., Ratnayaka, I., Corada, M., Bou-Gharios, G., Carroll, J., Dejana, E., Schulte-Merker, S., Hogan, B., Beltrame, M., De Val, S., Francois, M. (2017) SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development (Cambridge, England). 144(14):2629-2639
Overman, J., Fontaine, F., Moustaqil, M., Mittal, D., Sierecki, E., Sacilotto, N., Zuegg, J., Robertson, A.A., Holmes, K., Salim, A.A., Mamidyala, S., Butler, M.S., Robinson, A.S., Lesieur, E., Johnston, W., Alexandrov, K., Black, B.L., Hogan, B.M., Val, S., Capon, R.J., Carroll, J.S., Bailey, T.L., Koopman, P., Jauch, R., Smyth, M.J., Cooper, M.A., Gambin, Y., Francois, M. (2017) Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLIFE. 6
Koltowska, K., Lagendijk, A.K., Pichol-Thievend, C., Fischer, J.C., Francois, M., Ober, E.A., Yap, A.S., Hogan, B.M. (2015) Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports. 13:1828-41
Koltowska, K., Paterson, S., Bower, N.I., Baillie, G.J., Lagendijk, A.K., Astin, J.W., Chen, H., Francois, M., Crosier, P.S., Taft, R.J., Simons, C., Smith, K.A., Hogan, B.M. (2015) mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes & Development. 29:1618-30
Duong, T., Koltowska, K., Pichol-Thievend, C., Le Guen, L., Fontaine, F., Smith, K.A., Truong, V., Skoczylas, R., Stacker, S.A., Achen, M.G., Koopman, P., Hogan, B.M., and Francois, M. (2014) VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 123(7):1102-12
Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
Herpers, R., van de Kamp, E., Duckers, H.J., and Schulte-Merker, S. (2008) Redundant Roles for Sox7 and Sox18 in Arteriovenous Specification in Zebrafish. Circulation research. 102(1):12-15

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