ZFIN Morpholino: MO1-klf6a

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-klf6a

No data available

Phenotype

Phenotype resulting from MO1-klf6a

Phenotype	Fish	Figures
blood island cell cycle process quality, abnormal	sd2Tg + MO1-klf6a	Fig. 6 from Xue et al., 2015
blood island cell population proliferation decreased process quality, abnormal	sd2Tg + MO1-klf6a	Fig. 6 from Xue et al., 2015
caudal hematopoietic tissue hematopoietic multipotent progenitor cell decreased amount, abnormal	la2Tg; s896Tg + MO1-klf6a	Fig. 3 from Xue et al., 2017
caudal hematopoietic tissue hematopoietic stem cell decreased amount, abnormal	ioz1Tg; s896Tg + MO1-klf6a	Fig. 3 from Xue et al., 2017
caudal hematopoietic tissue hematopoietic stem cell proliferation decreased occurrence, abnormal	TU + MO1-klf6a	Fig. 3 from Xue et al., 2017

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Phenotype of all Fish created by or utilizing MO1-klf6a

Phenotype	Fish	Conditions	Figures
intermediate cell mass of mesoderm posterior region ccl25b expression decreased amount, abnormal	TU + MO1-klf6a	standard conditions	Fig. 5 from Xue et al., 2017
whole organism posterior region ccl25b expression decreased amount, abnormal	TU + MO1-klf6a	standard conditions	Fig. 5 from Xue et al., 2017
caudal hematopoietic tissue hematopoietic stem cell proliferation decreased occurrence, abnormal	TU + MO1-klf6a	standard conditions	Fig. 3 from Xue et al., 2017
erythrocyte maturation arrested, abnormal	WT + MO1-klf6a	standard conditions	Fig. 5 from Xue et al., 2015
nucleate erythrocyte decreased amount, abnormal	WT + MO1-klf6a	standard conditions	Fig. 5 , Fig. 6 from Xue et al., 2015

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Citations

Include unpublished citations

Wen, L., Zhang, T., Wang, J., Jin, X., Rouf, M.A., Luo, D., Zhu, Y., Lei, D., Gregersen, H., Wang, Y., Wang, G. (2021) The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics. PLoS Genetics. 17:e1009690
Xue, Y., Lv, J., Zhang, C., Wang, L., Ma, D., Liu, F. (2017) The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b. Developmental Cell. 42(4):349-362.e4
Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27
Veldman, M.B., Bemben, M.A., and Goldman, D. (2010) Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Molecular and cellular neurosciences. 43(4):370-383
Veldman, M.B., Bemben, M.A., Thompson, R.C., and Goldman, D. (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. 312(2):596-612

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