ZFIN Morpholino: MO1-amotl2a

Target Location

Genome Build: GRCz11Chromosome: 6

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-amotl2a

No data available

Phenotype

Phenotype resulting from MO1-amotl2a

Phenotype	Fish	Figures
angiogenesis disrupted, abnormal	y1Tg + MO1-amotl2a	Fig. 1 from Wang et al., 2011
blastodisc anatomical margin dharma expression increased amount, abnormal	TU + MO1-amotl2a	Fig. 1 from Li et al., 2012
blastodisc anatomical margin dharma expression increased distribution, abnormal	TU + MO1-amotl2a	Fig. 1 from Li et al., 2012
blastodisc anatomical margin dharma expression spatial pattern, abnormal	TU + MO1-amotl2a	Fig. 1 from Li et al., 2012
blood vessel unlumenized, abnormal	y1Tg + MO1-amotl2a	Fig. 1 from Wang et al., 2011

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Phenotype of all Fish created by or utilizing MO1-amotl2a

Phenotype	Fish	Conditions	Figures
cell migration disrupted, abnormal	TU + MO1-amotl2a	standard conditions	Fig. 5 , text only from Huang et al., 2007
filopodium assembly disrupted, abnormal	TU + MO1-amotl2a	standard conditions	Fig. 5 from Huang et al., 2007
whole organism yolk syncytial layer cellular motility, abnormal	TU + MO1-amotl2a	standard conditions	text only from Huang et al., 2007
convergent extension decreased rate, abnormal	TU + MO1-amotl2a	standard conditions	Fig. 4 from Huang et al., 2007
whole organism forerunner cell group cellular motility, abnormal	TU + MO1-amotl2a	standard conditions	text only from Huang et al., 2007

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Citations

Include unpublished citations

Hildebrand, S., Hultin, S., Subramani, A., Petropoulos, S., Zhang, Y., Cao, X., Mpindi, J., Kalloniemi, O., Johansson, S., Majumdar, A., Lanner, F., Holmgren, L. (2017) The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Scientific Reports. 7:9540
Hultin, S., Subramani, A., Hildebrand, S., Zheng, Y., Majumdar, A., Holmgren, L. (2017) AmotL2 integrates polarity and junctional cues to modulate cell shape. Scientific Reports. 7:7548
Agarwala, S., Duquesne, S., Liu, K., Boehm, A., Grimm, L., Link, S., König, S., Eimer, S., Ronneberger, O., Lecaudey, V. (2015) Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. eLIFE. 4:e08201
Hultin, S., Zheng, Y., Mojallal, M., Vertuani, S., Gentili, C., Balland, M., Milloud, R., Belting, H.G., Affolter, M., Helker, C.S., Adams, R.H., Herzog, W., Uhlen, P., Majumdar, A., Holmgren, L. (2014) AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nature communications. 5:3743
Li, Z., Wang, Y., Zhang, M., Xu, P., Huang, H., Wu, D., and Meng, A. (2012) Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish embryoys. The Journal of biological chemistry. 287(16):13005-13015
Wang, Y., Li, Z., Xu, P., Huang, L., Tong, J., Huang, H., and Meng, A. (2011) Angiomotin-like2 Gene (amotl2) Is Required for Migration and Proliferation of Endothelial Cells during Angiogenesis. The Journal of biological chemistry. 286(47):41095-104
Huang, H., Lu, F.I., Jia, S., Meng, S., Cao, Y., Wang, Y., Ma, W., Yin, K., Wen, Z., Peng, J., Thisse, C., Thisse, B., and Meng, A. (2007) Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development (Cambridge, England). 134(5):979-988

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