ZFIN Morpholino: MO1-dcc

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-dcc

No data available

Phenotype

Phenotype resulting from MO1-dcc

Phenotype	Fish	Figures
branching involved in lymph vessel morphogenesis process quality, abnormal	y1Tg/+ + MO1-dcc	Fig. 4 from Lim et al., 2011
commissural neuron axon guidance process quality, abnormal	WT + MO1-dcc	Fig. 4 from Sun et al., 2016
CoPA axon extension involved in axon guidance decreased process quality, abnormal	WT + MO1-dcc	Fig. 4 from Sun et al., 2016
CoPA neuron projection misrouted, abnormal	WT + MO1-dcc	Fig. 4 from Sun et al., 2016
dendrite development disrupted, abnormal	rw0Tg + MO1-dcc	Fig. 3 from Suli et al., 2006

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Phenotype of all Fish created by or utilizing MO1-dcc

Phenotype	Fish	Conditions	Figures
VaP motor neuron axon protruding into muscle pioneer, abnormal	WT + MO1-dcc	standard conditions	Fig. 5 from Hale et al., 2011
commissural neuron axon guidance process quality, abnormal	WT + MO1-dcc	standard conditions	Fig. 4 from Sun et al., 2016
CoPA neuron projection misrouted, abnormal	WT + MO1-dcc	standard conditions	Fig. 4 from Sun et al., 2016
CoPA axon extension involved in axon guidance decreased process quality, abnormal	WT + MO1-dcc	standard conditions	Fig. 4 from Sun et al., 2016
branching involved in lymph vessel morphogenesis process quality, abnormal	y1Tg/+ + MO1-dcc	standard conditions	Fig. 4 from Lim et al., 2011

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Citations

Include unpublished citations

Sun, S.D., Purdy, A.M., Walsh, G.S. (2016) Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neuroscience. 17:83
Bonner, J., Letko, M., Nikolaus, O.B., Krug, L., Cooper, A., Chadwick, B., Conklin, P., Lim, A., Chien, C.B., and Dorsky, R.I. (2012) Midline crossing is not required for subsequent pathfinding decisions in commissural neurons. Neural Development. 7(1):18
Gao, J., Zhang, C., Yang, B., Sun, L., Zhang, C., Westerfield, M., and Peng, G. (2012) Dcc Regulates Asymmetric Outgrowth of Forebrain Neurons in Zebrafish. PLoS One. 7(5):e36516
Gaudin, A., Hofmeister, W., and Key, B. (2012) Chemoattractant axon guidance cues regulate de novo axon trajectories in the embryonic forebrain of zebrafish. Developmental Biology. 367(2):126-139
Lakhina, V., Marcaccio, C.L., Shao, X., Lush, M.E., Jain, R.A., Fujimoto, E., Bonkowsky, J.L., Granato, M., and Raper, J.A. (2012) Netrin/DCC Signaling Guides Olfactory Sensory Axons to Their Correct Location in the Olfactory Bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(13):4440-4456
Zhang, C., Gao, J., Zhang, H., Sun, L., and Peng, G. (2012) Robo2-Slit and Dcc-Netrin1 Coordinate Neuron Axonal Pathfinding within the Embryonic Axon Tracts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(36):12589-12602
Hale, L.A., Fowler, D.K., and Eisen, J.S. (2011) Netrin Signaling Breaks the Equivalence between Two Identified Zebrafish Motoneurons Revealing a New Role of Intermediate Targets. PLoS One. 6(10):e25841
Lim, A.H., Suli, A., Yaniv, K., Weinstein, B., Li, D.Y., and Chien, C.B. (2011) Motoneurons are essential for vascular pathfinding. Development (Cambridge, England). 138(17):3847-3857
Kastenhuber, E., Kern U., Bonkowsky, J.L., Chien, C.B., Driever, W., and Schweitzer, J. (2009) Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(28):8914-8926
Suli, A., Mortimer, N., Shepherd, I., and Chien, C.B. (2006) Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(51):13328-13337

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