ZFIN Morpholino: MO1-myd88

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-myd88

No data available

Phenotype

Phenotype resulting from MO1-myd88

Phenotype	Fish	Figures
intermediate cell mass of mesoderm hematopoietic cell decreased amount, abnormal	la2Tg + MO1-myd88	Fig. 2 from He et al., 2015
T cell decreased amount, abnormal	TU + MO1-myd88	Fig. 2 from He et al., 2015
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal	TU + MO1-myd88	Fig. 2, Fig. 3 from He et al., 2015

1 - 3 of 3

Phenotype of all Fish created by or utilizing MO1-myd88

Phenotype	Fish	Conditions	Figures
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal	TU + MO1-myd88	standard conditions	Fig. 2, Fig. 3 from He et al., 2015
T cell decreased amount, abnormal	TU + MO1-myd88	standard conditions	Fig. 2 from He et al., 2015
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal	hkz010tTg + MO1-myd88	control	Fig. 3 from He et al., 2015
intermediate cell mass of mesoderm hematopoietic cell decreased amount, abnormal	la2Tg + MO1-myd88	standard conditions	Fig. 2 from He et al., 2015
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal	s896Tg; zf169Tg + MO1-myd88	standard conditions	Fig. 2, Fig. 3 from He et al., 2015

1 - 5 of 6 Show all

Citations

Include unpublished citations

Cafora, M., Brix, A., Forti, F., Loberto, N., Aureli, M., Briani, F., Pistocchi, A. (2020) Phages as immunomodulators and their promising use as anti-inflammatory agents in a cftr loss-of-function zebrafish model. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 20(6):1046-1052
Huang, C., Niethammer, P. (2018) Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish. Immunity. 48:1006-1013.e6
Mesureur, J., Feliciano, J.R., Wagner, N., Gomes, M.C., Zhang, L., Blanco-Gonzalez, M., van der Vaart, M., O'Callaghan, D., Meijer, A.H., Vergunst, A.C. (2017) Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS pathogens. 13:e1006437
Chang, M.Y., Cheng, Y.C., Hsu, S.H., Ma, T.L., Chou, L.F., Hsu, H.H., Tian, Y.C., Chen, Y.C., Sun, Y.J., Hung, C.C., Pan, R.L., Yang, C.W. (2016) Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. Scientific Reports. 6:27838
He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 125(7):1098-106
van der Vaart, M., van Soest, J.J., Spaink, H.P., and Meijer, A.H. (2013) Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Disease models & mechanisms. 6(3):841-54
Galindo-Villegas, J., García-Moreno, D., de Oliveira, S., Meseguer, J., and Mulero, V. (2012) Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 109(39):E2605-2614
Liu, Y., Li, M., Fan, S., Lin, Y., Lin, B., Luo, F., Zhang, C., Chen, S., Li, Y., and Xu, A. (2010) A Unique Feature of Toll/IL-1 Receptor Domain-Containing Adaptor Protein Is Partially Responsible for Lipopolysaccharide Insensitivity in Zebrafish with a Highly Conserved Function of Myd88. Journal of immunology (Baltimore, Md. : 1950). 185(6):3391-3400
Sepulcre, M.P., Alcaraz-Pérez, F., López-Muñoz, A., Roca, F.J., Meseguer, J., Cayuela, M.L., and Mulero, V. (2009) Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. Journal of immunology (Baltimore, Md. : 1950). 182(4):1836-1845
Stockhammer, O.W., Zakrzewska, A., Hegedûs, Z., Spaink, H.P., and Meijer, A.H. (2009) Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. Journal of immunology (Baltimore, Md. : 1950). 182(9):5641-5653

1 - 10 of 12

Show