ZFIN Morpholino: MO1-aldh1a2

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-aldh1a2

No data available

Phenotype

Phenotype resulting from MO1-aldh1a2

Phenotype	Fish	Figures
cornea increased thickness, abnormal	WT + MO1-aldh1a2 + MO4-tp53	Fig. 8 from Bohnsack et al., 2012
corneal endothelium absent, abnormal	WT + MO1-aldh1a2 + MO4-tp53	Fig. 8 from Bohnsack et al., 2012
corneal epithelium scalloped, abnormal	WT + MO1-aldh1a2 + MO4-tp53	Fig. 8 from Bohnsack et al., 2012
head anterior-posterior axis decreased length, abnormal	WT + MO1-aldh1a2 + MO4-tp53	Fig. 8 from Bohnsack et al., 2012
lens decreased size, abnormal	WT + MO1-aldh1a2 + MO4-tp53	Fig. 8 from Bohnsack et al., 2012

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Phenotype of all Fish created by or utilizing MO1-aldh1a2

Phenotype	Fish	Conditions	Figures
retinoic acid receptor signaling pathway process quality, abnormal	WT + MO1-aldh1a2	standard conditions	Fig. 4 from Vaccari et al., 2010
pharyngeal arch 3-7 physical object quality, abnormal	WT + MO1-aldh1a2	standard conditions	Fig. 4 from Vaccari et al., 2010
somite decreased amount, abnormal	WT + MO1-aldh1a2	standard conditions	Fig. 2 from Retnoaji et al., 2014
vertebra 2 absent, abnormal	WT + MO1-aldh1a2	standard conditions	Fig. 2 from Retnoaji et al., 2014
somite 4 somitogenesis increased duration, abnormal	WT + MO1-aldh1a2	standard conditions	Fig. 1 from Retnoaji et al., 2014

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Citations

Include unpublished citations

Williams, A.L., Eason, J., Chawla, B., Bohnsack, B.L. (2017) Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway. Investigative ophthalmology & visual science. 58:1084-1097
Li, J., Yue, Y., Zhao, Q. (2016) Retinoic Acid Signaling Is Essential for Valvulogenesis by Affecting Endocardial Cushions Formation in Zebrafish Embryos. Zebrafish. 13(1):9-18
Sosnik, J., Zheng, L., Rackauckas, C.V., Digman, M., Gratton, E., Nie, Q., Schilling, T.F. (2016) Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. eLIFE. 5:e14034
Retnoaji, B., Akiyama, R., Matta, T., Bessho, Y., and Matsui, T. (2014) Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anteroposterior somitogenetic rate difference. Development (Cambridge, England). 141(1):158-165
Bohnsack, B.L., Kasprick, D.S., Kish, P.E., Goldman, D., and Kahana, A. (2012) A zebrafish model of Axenfeld-Rieger Syndrome reveals that pitx2 regulation by retinoic acid is essential for ocular and craniofacial development. Investigative ophthalmology & visual science. 53(1):7-22
Vaccari, E., Deflorian, G., Bernardi, E., Pauls, S., Tiso, N., Bortolussi, M., and Argenton, F. (2010) prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Developmental Biology. 343(1-2):94-103
Laue, K., Jänicke, M., Plaster, N., Sonntag, C., and Hammerschmidt, M. (2008) Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. Development (Cambridge, England). 135(22):3775-3787
Eisinger, A.L., Nadauld, L.D., Shelton, D.N., Prescott, S.M., Stafforini, D.M., and Jones, D.A. (2007) Retinoic Acid Inhibits β-Catenin through Suppression of Cox-2: A role for truncated adenomatous polyposis coli. The Journal of biological chemistry. 282(40):29394-29400
White, R.J., Nie, Q., Lander, A.D., and Schilling, T.F. (2007) Complex Regulation of cyp26a1 Creates a Robust Retinoic Acid Gradient in the Zebrafish Embryo. PLoS Biology. 5(11):e304
Emoto, Y., Wada, H., Okamoto, H., Kudo, A., and Imai, Y. (2005) Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish. Developmental Biology. 278(2):415-427

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