ZFIN Morpholino: MO1-tbxta

Target Location

Genome Build: GRCz11Chromosome: 19

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tbxta

No data available

Phenotype

Phenotype resulting from MO1-tbxta

Phenotype	Fish	Figures
axial chorda mesoderm fgf8a expression absent, abnormal	WT + MO1-tbxta	Fig. 4 from Osborn et al., 2020
calcium/calmodulin-dependent protein kinase activity decreased rate, abnormal	WT + MO1-tbxta	Fig. 7 from Francescatto et al., 2010
determination of digestive tract left/right asymmetry decreased process quality, abnormal	pd24Tg + MO1-tbxta	Fig. 6 from Hochgreb-Hägele et al., 2013
determination of heart left/right asymmetry disrupted, abnormal	WT + MO1-tbxta	Fig. 2 from Hatler et al., 2009
embryonic heart tube left/right pattern formation process quality, abnormal	twu34Tg + MO1-tbxta	Fig. 1 from Lenhart et al., 2013

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Phenotype of all Fish created by or utilizing MO1-tbxta

Phenotype	Fish	Conditions	Figures
post-vent region shape, abnormal	AB + MO1-tbxta	standard conditions	Fig. 8 from Amack et al., 2007
Kupffer's vesicle unlumenized, abnormal	AB + MO1-tbxta	standard conditions	Fig. 7 from Amack et al., 2007
trunk morphology, abnormal	AB + MO1-tbxta	standard conditions	Fig. 8 from Amack et al., 2007
nodal signaling pathway disrupted, abnormal	WT + MO1-tbxta	standard conditions	Fig. 5 from Roussigné et al., 2009
determination of heart left/right asymmetry disrupted, abnormal	WT + MO1-tbxta	standard conditions	Fig. 2 from Hatler et al., 2009

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Citations

Include unpublished citations

Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):
Roussigné, M., Wei, L., Tsingos, E., Kuchling, F., Alkobtawi, M., Tsalavouta, M., Wittbrodt, J., Carl, M., Blader, P., Wilson, S.W. (2018) Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells. Proceedings of the National Academy of Sciences of the United States of America. 115(42):E9812-E9821
Pelliccia, J.L., Jindal, G.A., Burdine, R.D. (2017) Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. eLIFE. 6
Burdine, R.D., Grimes, D.T. (2016) Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 371(1710)
Khuansuwan, S., Clanton, J.A., Dean, B.J., Patton, J.G., Gamse, J.T. (2016) A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex. Development (Cambridge, England). 143(14):2641-50
Hochgreb-Hägele, T., Yin, C., Koo, D.E., Bronner, M.E., and Stainier, D.Y. (2013) Laminin beta1a controls distinct steps during the establishment of digestive organ laterality. Development (Cambridge, England). 140(13):2734-2745
Huang, C.J., Wilson, V., Pennings, S., MacRae, C.A., and Mullins, J. (2013) Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Developmental Biology. 384(2):290-300
Lenhart, K.F., Holtzman, N.G., Williams, J.R., and Burdine, R.D. (2013) Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left-Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry. PLoS Genetics. 9(1):e1003109
Qian, M., Yao, S., Jing, L., He, J., Xiao, C., Zhang, T., Meng, W., Zhu, H., Xu, H., and Mo, X. (2013) ENC1-like Integrates the Retinoic Acid/FGF Signaling Pathways to Modulate Ciliogenesis of Kupffer's Vesicle during Zebrafish Embryonic Development. Developmental Biology. 374(1):85-95
Sittaramane, V., Pan, X., Glasco, D.M., Huang, P., Gurung, S., Bock, A., Li, S., Wang, H., Kawakami, K., Matise, M.P., and Chandrasekhar, A. (2013) The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Developmental Biology. 382(2):400-412

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