ZFIN Morpholino: MO1-notch3

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-notch3

No data available

Phenotype

Phenotype resulting from MO1-notch3

No data available

Phenotype of all Fish created by or utilizing MO1-notch3

Phenotype	Fish	Conditions	Figures
rhombomere boundary formation disrupted, abnormal	notch1a^th35b/th35b + MO1-notch3	standard conditions	Fig. 5 from Qiu et al., 2009
neural tube morphology, abnormal	notch1a^th35b/th35b + MO1-notch3	standard conditions	Fig. 5 from Qiu et al., 2009
hindbrain neuroepithelial cell aggregated, abnormal	notch1a^th35b/th35b + MO1-notch3	standard conditions	Fig. 5 from Qiu et al., 2009
ectoderm development disrupted, abnormal	notch1a^th35b/th35b + MO1-notch3	standard conditions	Fig. 4 from Hsiao et al., 2007
hindbrain neuron increased amount, abnormal	notch1a^th35b/th35b + MO1-notch3	standard conditions	Fig. 5 from Qiu et al., 2009

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Citations

Include unpublished citations

Sahu, A., Devi, S., Jui, J., Goldman, D. (2021) Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia. 69(12):2882-2898
Ando, K., Wang, W., Peng, D., Chiba, A., Lagendijk, A., Barske, L., Crump, J.G., Stainier, D.Y.R., Lendahl, U., Koltowska, K., Hogan, B.M., Fukuhara, S., Mochizuki, N., Betsholtz, C. (2019) Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. Development (Cambridge, England). 146(2):
Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047
Kressmann, S., Campos, C., Castanon, I., Fürthauer, M., González-Gaitán, M. (2015) Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord. Nature cell biology. 17(3):333-9
Wang, Y., Pan, L., Moens, C.B., and Appel, B. (2014) Notch3 establishes brain vascular integrity by regulating pericyte number. Development (Cambridge, England). 141(2):307-317
Da'as, S.I., Coombs, A.J., Balci, T.B., Grondin, C.A., Ferrando, A.A., and Berman, J.N. (2012) The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 119(15):3585-3594
Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 30(9):1695-1702
Ishitani, T., Hirao, T., Suzuki, M., Isoda, M., Ishitani, S., Harigaya, K., Kitagawa, M., Matsumoto, K., and Itoh, M. (2010) Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nature cell biology. 12(3):278-285
Matsuda, M., and Chitnis, A.B. (2010) Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish. Development (Cambridge, England). 137(20):3477-3487
Matsuda, M., and Chitnis, A.B. (2009) Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue. Development (Cambridge, England). 136(2):197-206

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