ZFIN Morpholino: MO1-jag2b

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-jag2b

No data available

Phenotype

Phenotype resulting from MO1-jag2b

Phenotype	Fish	Figures
cell differentiation involved in pronephros development disrupted, abnormal	WT + MO1-jag2b	Fig. 5 from Liu et al., 2007
dorsal aorta hematopoietic stem cell myb expression decreased amount, abnormal	AB + MO1-jag2b	Fig. 2 from Wada et al., 2022
pectoral fin actin filament mislocalised, abnormal	WT + MO1-jag2b	Fig. 4 from Pascoal et al., 2013
pectoral fin endoskeletal disc disorganized, abnormal	WT + MO1-jag2b	Fig. 2 from Pascoal et al., 2013
pectoral fin musculature contractile muscle fiber malformed, abnormal	WT + MO1-jag2b	Fig. 4 from Pascoal et al., 2013

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Phenotype of all Fish created by or utilizing MO1-jag2b

Phenotype	Fish	Conditions	Figures
dorsal aorta hematopoietic stem cell myb expression decreased amount, abnormal	AB + MO1-jag2b	standard conditions	Fig. 2 from Wada et al., 2022
pectoral fin musculature contractile muscle fiber malformed, abnormal	WT + MO1-jag2b	standard conditions	Fig. 4 from Pascoal et al., 2013
pectoral fin endoskeletal disc disorganized, abnormal	WT + MO1-jag2b	standard conditions	Fig. 2 from Pascoal et al., 2013
pectoral fin actin filament mislocalised, abnormal	WT + MO1-jag2b	standard conditions	Fig. 4 from Pascoal et al., 2013
pronephros multi-ciliated epithelial cell increased amount, abnormal	WT + MO1-jag2b	standard conditions	Fig. 5 from Liu et al., 2007

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Citations

Include unpublished citations

Jacobs, C.T., Kejriwal, A., Kocha, K.M., Jin, K.Y., Huang, P. (2022) Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. Developmental Biology. 489:1-13
Wada, Y., Tsukatani, H., Kuroda, C., Miyazaki, Y., Otoshi, M., Kobayashi, I. (2022) Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish. Development (Cambridge, England). 149(7)
Zhao, C., Matalonga, J., Lancman, J.J., Liu, L., Xiao, C., Kumar, S., Gates, K.P., He, J., Graves, A., Huisken, J., Azuma, M., Lu, Z., Chen, C., Ding, B.S., Dong, P.D.S. (2022) Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201097119e2201097119
Zhao, C., Lancman, J.J., Yang, Y., Gates, K.P., Cao, D., Barske, L., Matalonga, J., Pan, X., He, J., Graves, A., Huisken, J., Chen, C., Dong, P.D.S. (2021) Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome. Hepatology (Baltimore, Md.). 75(3):567-583
Zhang, D., Gates, K.P., Barske, L., Wang, G., Lancman, J.J., Zeng, X.I., Groff, M., Wang, K., Parsons, M.J., Crump, J.G., Dong, P.D.S. (2017) Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nature communications. 8:769
Pascoal, S., Esteves de Lima, J., Leslie, J.D., Hughes, S.M., and Saúde, L. (2013) Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish. PLoS One. 8(6):e68021
Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 30(9):1695-1702
Bill, B.R., Balciunas, D., McCarra, J.A., Young, E.D., Xiong, T., Spahn, A.M., Garcia-Lecea, M., Korzh, V., Ekker, S.C., and Schimmenti, L.A. (2008) Development and notch signaling requirements of the zebrafish choroid plexus. PLoS One. 3(9):e3114
Jänicke, M., Carney, T.J., and Hammerschmidt, M. (2007) Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo. Developmental Biology. 307(2):258-271
Liu, Y., Pathak, N., Kramer-Zucker, A., and Drummond, I.A. (2007) Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development (Cambridge, England). 134(6):1111-1122

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