Gene

jag2b

ID
ZDB-GENE-011128-3
Name
jagged canonical Notch ligand 2b
Symbol
jag2b Nomenclature History
Previous Names
  • jag2
  • jagged2
  • serB
  • serrateB
  • unp1068
  • zgc:152855
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable Notch binding activity and calcium ion binding activity. Acts upstream of or within several processes, including exocrine pancreas development; hematopoietic stem cell differentiation; and ventral spinal cord development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
46 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hu3425Allele with one point mutationUnknownPremature StopENU
ihb328Allele with one delinsExon 23UnknownCRISPR
ihb329Allele with one delinsExon 2UnknownCRISPR
ihb330Allele with one deletionExon 2UnknownCRISPR
ihb331Allele with one deletionUnknownUnknownCRISPR
ihb344Allele with one delinsExon 2UnknownCRISPR
ion27hTgTransgenic insertionUnknownUnknownDNA and CRISPR
ion28hAllele with one delinsExon 2UnknownCRISPR
kz6Allele with one deletionExon 2UnknownCRISPR
kz7Allele with one deletionExon 2UnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With jag2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 27 Alliance Muscular dystrophy, limb-girdle, autosomal recessive 27 619566
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Associated With jag2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
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Domain Details Per Protein
Protein Additional Resources Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Jagged/Serrate protein Notch ligand, N-terminal domain VWFC domain
UniProtKB:Q5TZK7 InterPro 1216
UniProtKB:Q90Y56 InterPro 1254
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA jag2b-201 (1) Ensembl 5,438 nt
mRNA jag2b-202 (1) Ensembl 5,324 nt
mRNA jag2b-204 (1) Ensembl 1,407 nt
ncRNA jag2b-003 (1) Ensembl 812 nt
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Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(UAS:jag2b-2A-Hsa.HIST1H2BJ-ECFP,myh7:mCherry)
  • Danio rerio
  • Homo sapiens
1Jin et al., 2022
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-194O4ZFIN Curated Data
Contained inBACDKEY-5P1ZFIN Curated Data
EncodesESTaf090432
EncodesESTeu1049Thisse et al., 2005
EncodescDNAcssl:d403Bushell et al., 2007
EncodescDNAMGC:152855ZFIN Curated Data
EncodescDNAMGC:195316ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanJAG214
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseJag212
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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