Gene
jag2b
- ID
- ZDB-GENE-011128-3
- Name
- jagged canonical Notch ligand 2b
- Symbol
- jag2b Nomenclature History
- Previous Names
-
- jag2
- jagged2
- serB
- serrateB
- unp1068
- zgc:152855
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity and calcium ion binding activity. Acts upstream of or within several processes, including exocrine pancreas development; hematopoietic stem cell differentiation; and ventral spinal cord development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1049 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3425 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ihb328 | Allele with one delins | Exon 23 | Unknown | CRISPR | |
| ihb329 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| ihb330 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb331 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb344 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| ion27hTg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ion28h | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| kz6 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| kz7 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-jag2b | (2) | |
| CRISPR2-jag2b | Zebrafish Nomenclature Committee | |
| CRISPR3-jag2b | (3) | |
| CRISPR4-jag2b | (2) | |
| CRISPR5-jag2b | (2) | |
| CRISPR6-jag2b | (2) | |
| CRISPR7-jag2b | Jin et al., 2022 | |
| CRISPR8-jag2b | Jin et al., 2022 | |
| MO1-jag2b | N/A | (14) |
| MO2-jag2b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive limb-girdle muscular dystrophy type 27 | Alliance | Muscular dystrophy, limb-girdle, autosomal recessive 27 | 619566 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Jagged/Serrate protein | Notch ligand, N-terminal domain | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TZK7 | InterPro | 1216 | ||||||||||
| UniProtKB:Q90Y56 | InterPro | 1254 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:jag2b-2A-Hsa.HIST1H2BJ-ECFP,myh7:mCherry) |
| 1 | Jin et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194O4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-5P1 | ZFIN Curated Data | |
| Encodes | EST | af090432 | ||
| Encodes | EST | eu1049 | Thisse et al., 2005 | |
| Encodes | cDNA | cssl:d403 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:152855 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195316 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131862 (1) | 5469 nt | ||
| Genomic | GenBank:BX004766 (2) | 214782 nt | ||
| Polypeptide | UniProtKB:Q90Y56 (1) | 1254 aa |
- Ercanbrack, W.S., Dungan, A., Gaul, E., Ramirez, M., J DelVecchio, A., Grass, C., Wingert, R.A. (2024) Frataxin is essential for zebrafish embryogenesis and pronephros formation. Frontiers in cell and developmental biology. 12:14962441496244
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wesselman, H.M., Flores-Mireles, A.L., Bauer, A., Pei, L., Wingert, R.A. (2023) Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis. Development (Cambridge, England). 150(10):
- Jacobs, C.T., Kejriwal, A., Kocha, K.M., Jin, K.Y., Huang, P. (2022) Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. Developmental Biology. 489:1-13
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Wada, Y., Tsukatani, H., Kuroda, C., Miyazaki, Y., Otoshi, M., Kobayashi, I. (2022) Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish. Development (Cambridge, England). 149(7)
- Zhao, C., Matalonga, J., Lancman, J.J., Liu, L., Xiao, C., Kumar, S., Gates, K.P., He, J., Graves, A., Huisken, J., Azuma, M., Lu, Z., Chen, C., Ding, B.S., Dong, P.D.S. (2022) Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201097119e2201097119
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