ZFIN Image: Monfries et al., 2025, Fig. 4

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Figure Caption

Fig. 4 fzd5sgu1 and fzd5sgu3 are genetically sensitised to developing eye malformations. (A,B,D-F,H,I) Lateral views, with anterior to the left, of 72 hpf embryos treated with DMSO (A,D,H) or XAV-939 (B,E,F,I). Colobomas (arrows in B,F,I) are evident in a subset of embryos derived from the incross of fzd5sgu1/+ (B), MZfzd5sgu1 (F) and fzd5sgu3/+ XAV-939-treated embryos (I), a phenotype never observed in wild-type XAV-939-treated embryos (E). (C,G,J) Quantification of phenotypes observed, and their associated genotypes, in XAV-939-treated embryos derived from fzd5sgu1/+ incross (C), wild-type or MZfzd5sgu1 incross (G) and fzd5sgu3/+ incross (J). Scale bar: 500 µm.

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.