ZFIN Image: Konar et al., 2025, FIGURE 6

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FIGURE 6

Regeneration specific secretome signature. InteractiVenn based analysis was used to determine the presence of a conserved secretome signature. (A) Analysis of upregulated SASP factors and senescence markers from 4 acute damage datasets identified 31 conserved genes, referred to as the SASP-related Regeneration Factors (SRRFs). (B) Analysis of upregulated SASP factors and senescence markers in chronic damage datasets identified 3 conserved genes. (C) STRING analysis of the SRRFs showed both predicted and conserved protein-protein relationships between 25 of the 31 genes in the SRRF. (D) Reactome analysis of the SRRFs showed enrichment in processes related to antigen presentation, cellular transport, immune system processing, and aggrephagy.

Acknowledgments

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