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FIGURE 6
Coilin N‐terminal mutations similarly influence gene expression and predominately act independent of splicing events. (A, B) Venn diagrams illustrating the overlap in genes differentially expressed between ΔN1 and ΔN2 with WT upon PBS or LPS injection. (C, D) GO enrichment analysis illustrating the top general pathways altered under WT versus ΔN mutant comparisons under PBS or LPS injection. (E) Table highlighting a subset of genes found to be upregulated under PBS injection and downregulated under LPS injection in both ΔN mutants compared to WT. Boldened terms highlight immunity‐related genes. (F, H) rMATS analysis for the WT versus ΔN mutant comparisons under PBS or LPS injection. (G, I) Venn diagram showing the number of genes shared across DAS events and differential gene expression in the WT versus ΔN2 comparison under PBS or LPS injection.