ZFIN Image: Manickam et al., 2025, Figure 5

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Figure Caption

Figure 5

Assessment of clinical cisplatin treatment at the 16 kHz frequency region. Wave I amplitudes (A) and latencies (B) were analyzed for the 16 kHz region in age-matched control animals (black), and animals receiving saline solution (vehicle-control, white) or clinical cisplatin (3 mg/kg b.w., maroon). (C–E) Representative micrographs of the organ of Corti at the 16 kHz frequency region. Pre-synaptic ribbons were immunostained for CtBP2 (red). Hair cells were delineated with white traces. (C) Age-matched control. (D) Vehicle control. (E) Clinical cisplatin 3 mg/kg b.w. Scale bar = 5 μm. (F) Pre-synaptic ribbon quantification at the 16 kHz region for all the groups. Mean +/− SD. Circles represent individual animals. Statistical analysis: One-way ANOVA followed by Dunnett post-test for multiple comparisons. ns, not significant.

Acknowledgments

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