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Fig. 3 AURKBi induces p53 expression and cleaved caspase 3 in Grp 3 MB. A) IB of Barasertib treatment effects on AURKA,B,C phosphorylation (pThr232) and MYC and p53 protein levels after 6 h of treatment. B) IB of Barasertib treatment effects on AURKA,B,C phosphorylation and MYC, p53 protein levels and CC3 after 24 h of treatment. C-F) RT-qPCR quantifications of p21 and BAX mRNA levels in HD-MB03 (C,E) and D425 (D,F) cells. Cells were irradiated (IR, 1,8 Gy) and/or treated with Barasertib (50 nM) for 8 and 24 h (n=3 biological replicas).
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