ZFIN Image: Liu et al., 2025, Figure 2

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Figure 2

Transcriptomic profiles of tirap mutant and myd88 mutant zebrafish larvae measured by RNAseq. (A) Overview of the distribution of differentially expressed genes (DEGs) log2 fold change in tirap^-/- versus tirap^+/+ zebrafish larvae. (B) Overview of the distribution of DEGs log2 fold change in myd88^-/- versus myd88^+/+ zebrafish larvae. DEGs were assessed by padj value less than 0.05. Down-regulated gene sets are shown in blue, and up-regulated gene sets are shown in red. (C) KEGG pathway enrichment analysis of tirap^-/- versus tirap^+/+. (D) KEGG pathway enrichment analysis of myd88^-/- versus myd88^+/+. Significantly enriched KEGG pathway terms for DEGs of tirap^-/- versus tirap^+/+ groups were determined by using the hypergeometric test/Fisher's exact test, with a threshold of p value < 0.05, which were adjusted using the Benjamini and Hochbery FDR correction. For myd88^-/- versus myd88^+/+ group, significantly enriched KEGG pathway terms for DEGs were determined by using the hypergeometric test/Fisher's exact test, with a threshold of p value < 0.1.

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