ZFIN Image: Lee et al., 2024, FIGURE 1

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Figure Caption

FIGURE 1

Ablation of pancreatic β-cells induced depletion of insulin production in ins:epNTR-mCherry zebrafish. (A) Schematics of the transgenic zebrafish showing the ablation of pancreatic β-cells using epNTR-mediated chemogenetic ablation system. (B,C) In-vivo fluorescence images showing pancreatic β-cells in Ins:epNTR-mCherry larvae treated with DMSO (B) and MTZ (C) at 9 dpf. (D) Quantification of fluorescence intensity in mcherry-expressing pancreatic β-cells from panel (B) and (C), ****p < 0.0001, t-test (n = 12 larvae per group). (E) Quantification of expression of ins mRNA in transgenic larvae, ****p < 0.0001, t-test (n = 15 larvae per group). Scale bar, 20 μm in (B).

Acknowledgments

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