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Fig. 7 TEX264 expression level defines TOP1cc repair and the clinical response to irinotecan-based chemotherapy (A) Representative images of 2-day-old zebrafish and RT-qPCR quantification of tex264 expression. Two-way ANOVA. Error bar, SD. (B) RADAR assay in 2-day-old zebrafish (lanes 1 and 2, n = 4; lanes 3 and 4, n = 2). Double-stranded (ds) DNA; loading control. Error bar, SD. (C) Univariate Cox regression analysis of survival of colorectal cancer patients classified according to TEX264 mRNA expression. FOLFIRI: folinic acid, 5-fluorouracil (5-FU), and irinotecan. (D) Model. S, SUMOylation. ∗p < 0.05; ∗∗∗p < 0.0005; ns, not significant. See also Figure S7.
Reprinted from Cell, 187(20), Lascaux, P., Hoslett, G., Tribble, S., Trugenberger, C., Antičević, I., Otten, C., Torrecilla, I., Koukouravas, S., Zhao, Y., Yang, H., Aljarbou, F., Ruggiano, A., Song, W., Peron, C., Deangeli, G., Domingo, E., Bancroft, J., Carrique, L., Johnson, E., Vendrell, I., Fischer, R., Ng, A.W.T., Ngeow, J., D'Angiolella, V., Raimundo, N., Maughan, T., Popović, M., Milošević, I., Ramadan, K., TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival, 5698-5718.e26, Copyright (2024) with permission from Elsevier. Full text @ Cell