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Fig. 7 Multiple sequence alignment of TNF-α sequences among teleost fishes. Residues are numbered according to the sequence of zTNF-α1. Arrows above the alignment indicate β-strands, and cylinders indicate helixes. The total amino acid sequence identities between zTNF-α1 and the listed fish TNF-α sequences are shown to the right of the sequences. Blue highlighting indicates that the TNF-α residues that may interact with receptors are conserved in teleost fish. Hot pink indicates residues involved in the interactions between trimers that differ from those in humans. Green indicate inserted or deleted amino acids in this region compared with those in the human sequence. Orange markings indicate the unique structural characteristics of the amino acids of zTNF-α1.