ZFIN Image: Inderbinen et al., 2020, Fig. 6

Image

Figure Caption

Fig. 6 Comparison of the posaconazole-, itraconazole- and OHI-dependent inhibition of human and mouse 11β-HSD2 with that of chimera E, F and H. Lysates of HEK-293 cells expressing recombinant 11β-HSD2 of the indicated species or the respective chimera were incubated for 10 min (human) or 20 min (mouse, chimeras) with 50 nM cortisol, 500 μM NAD⁺ and 1 μM or 10 μM of the test compounds. Substrate conversion was normalized to that of the vehicle control (0.4% DMSO). Data represent mean ± SD from three independent experiments. Data were analyzed by two-way ANOVA with Bonferroni's post hoc test. P values: * < 0.05, ** < 0.01, **** < 0.0001 and ns (not significant), n.d. (not detected).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Tox. App. Pharmacol.