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Fig. 6

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ZDB-IMAGE-200817-27

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Publication

Bottiglione et al., 2020 - Zebrafish IL-4-like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis

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Fig. 6

Prolonged inflammatory response in il10^e46/e46 gills following R848 stimulation. (A) qPCR analysis showing transcript levels of il1β, il6, tnfα, and ifng1–2 in gills from wildtype and il10^e46/e46 animals following R848 challenge for 1 and 8 h. Gene expression was normalized to the expression of β−actin. Fold change is shown. Error bars represent SEM; n > 3, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (B) Representative images of sections (n = 3) of gills from wildtype and il10^e46/e46 animals (n = 3) stained with H&E following 8-h R848 challenge. Epithelial cell alteration in the lamellae (black arrows) and gill filament (stars) are indicated in gills from il10^e46/e46 animals. Scale bar, 50 μm. (C) Quantification of gill tissue damage in wildtype and il10^e46/e46 animals following R848 challenge.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Immunol.