IMAGE

Fig. S4

ID

ZDB-IMAGE-070219-8

Genes

en2b
hoxb1a

Publication

Hernandez et al., 2007 - Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development

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Figures for Hernandez et al., 2007

Image

Figure Caption

Fig. S4 cyp26 genes function redundantly to protect the anterior hindbrain from endogenous RA. cyp26a1 and cyp26c1 are responsible for setting the r3-r4 limit. (A,C,E,G) Knocking-down cyp26b1 and/or c1 has no effect on hindbrain patterning in wild-type embryos. (B) cyp26a1 mutants exhibit a mild expansion of r4. This effect is enhanced by knocking-down cyp26b1 (D), but hoxb1a expression is shifted to the presumptive cerebellum (En-expressing domains) by knocking-down cyp26c1 (F). Embryos depleted for all three cyp26 proteins exhibit a profound anterior shift of hoxb1 expression to the mid-hindbrain domain (H). Scale bar: 100 μm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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