Gene
hoxb1a
- ID
- ZDB-GENE-990415-101
- Name
- homeobox B1a
- Symbol
- hoxb1a Nomenclature History
- Previous Names
-
- hoxb1
- etID309950.3 (1)
- id:ibd3532
- sb:eu402
- Z-3
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within central nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain; mesoderm; neural keel; neural plate; and neural rod. Orthologous to human HOXB1 (homeobox B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 97 figures from 64 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu402 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1191 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31326 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33162 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| um189 | Allele with one deletion | Exon 1 | Unknown | TALEN | |
| um190 | Allele with one delins | Exon 1 | Unknown | TALEN | |
| um191 | Allele with one delins | Exon 1 | Unknown | TALEN | |
| um192 | Allele with one delins | Exon 1 | Unknown | TALEN | |
| um193 | Allele with one deletion | Exon 1 | Unknown | TALEN | |
| um194 | Allele with one delins | Exon 1 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxb1a | (2) | |
| CRISPR2-hoxb1a | Saunders et al., 2023 | |
| CRISPR3-hoxb1a | Saunders et al., 2023 | |
| MO1-hoxb1a | N/A | (13) |
| MO2-hoxb1a | N/A | Sundaramoorthi et al., 2023 |
| TALEN1-hoxb1a | Weicksel et al., 2014 | |
| TALEN2-hoxb1a | (4) | |
| TALEN3-hoxb1a | Weicksel et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Facial paresis, hereditary congenital, 3 | 614744 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Hox-A1/B1/D1 | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:B3DHZ4 | InterPro | 316 | |||||
| UniProtKB:O42366 | InterPro | 311 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxb1a-201
(1)
|
Ensembl | 1,507 nt | ||
| mRNA | ottdart00000001810 (1) | Havana | 1,860 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(hoxb1a:RFP) |
|
| 1 | (3) | |
| Tg(hoxb1a-Mmu.Hbb:EGFP) |
|
| 1 | (5) | |
| Tg(hoxb1a-Mmu.Hbb:GAL4-VP16) |
|
| 1 | (4) | |
| Tg(hoxb1a-SCP1:Ocu.Hbb2-Cre-2A-Cerulean) |
|
| 1 | Tabor et al., 2018 | |
| Tg(hsp70l:hoxb1a-MYC) |
|
| 1 | Labalette et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-178D9 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-254O17 | (2) | |
| Encodes | EST | eu402 | Thisse et al., 2005 | |
| Encodes | EST | ibd3532 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194377 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131115 (1) | 1069 nt | ||
| Genomic | GenBank:AL645782 (1) | 119385 nt | ||
| Polypeptide | UniProtKB:B3DHZ4 (1) | 316 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | HOXB1 | 17 | Conserved genome location (synteny) (4) Amino acid sequence comparison (4) Nucleotide sequence comparison (1) | |
| Mouse | Hoxb1 | 11 | Coincident expression (1) Conserved genome location (synteny) (2) Amino acid sequence comparison (3) Nucleotide sequence comparison (1) |
- Leino, S.A., Constable, S.C.J., Streit, A., Wilkinson, D.G. (2023) Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. Development (Cambridge, England). 150(18):
- Odelin, G., Faucherre, A., Marchese, D., Pinard, A., Jaouadi, H., Le Scouarnec, S., FranceGenRef Consortium, Chiarelli, R., Achouri, Y., Faure, E., Herbane, M., Théron, A., Avierinos, J.F., Jopling, C., Collod-Béroud, G., Rezsohazy, R., Zaffran, S. (2023) Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish. Nature communications. 14:15431543
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Qiu, Y., Fung, L., Schilling, T.F., Nie, Q. (2021) Multiple morphogens and rapid elongation promote segmental patterning during development. PLoS Computational Biology. 17:e1009077
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Beiriger, A., Narayan, S., Singh, N., Prince, V. (2020) Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons. The Journal of comparative neurology. 529(7):1293-1307
- Voltes, A., Hevia, C.F., Engel, C., Dingare, C., Calzolari, S., Terriente, J., Norden, C., Lecaudey, V., Pujades, C. (2019) Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation. Development (Cambridge, England). 146(14):
- Wang, H., Meng, Z., Zhou, L., Cao, Z., Liao, X., Ye, R., Lu, H. (2019) Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages. Chemosphere. 220:954-964
- Wang, H., Zhou, L., Liao, X., Meng, Z., Xiao, J., Li, F., Zhang, S., Cao, Z., Lu, H. (2019) Toxic effects of oxine-copper on development and behavior in the embryo-larval stages of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 210:242-250
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