Gene
jupa
- ID
- ZDB-GENE-991207-22
- Name
- junction plakoglobin a
- Symbol
- jupa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in Kupffer's vesicle development; adherens junction maintenance; and desmosome maintenance. Acts upstream of or within atrioventricular valve morphogenesis and negative regulation of Wnt signaling pathway. Located in several cellular components, including adherens junction; desmosome; and intercalated disc. Part of catenin complex. Is expressed in several structures, including EVL; ectoderm; forerunner cell group; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55216 (15 images)
- cb80 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct520aGt | Transgenic insertion | Unknown | Unknown | DNA | |
| ihb860 | Allele with one deletion | Exon 9 | Unknown | CRISPR | |
| ihb861 | Allele with one delins | Unknown | Unknown | not specified | |
| la011634Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12692 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12961 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14171 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31818 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-jupa | Zebrafish Nomenclature Committee | |
| MO1-jupa | N/A | (4) |
| MO2-jupa | N/A | Dasgupta et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| arrhythmogenic right ventricular dysplasia 12 | Alliance | ?Arrhythmogenic right ventricular dysplasia 12 | 611528 |
| Naxos disease | Alliance | Naxos disease | 601214 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Beta-catenin |
|---|---|---|---|---|---|---|
| UniProtKB:Q9PVF7 | InterPro | 729 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-jup | monoclonal | IgG2a | Mouse |
|
BD Biosciences
|
6 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(her4.1:jupa-EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-8O15 | ZFIN Curated Data | |
| Encodes | EST | cb80 | Thisse et al., 2001 | |
| Encodes | EST | fb11b06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55216 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65740 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131177 (1) | 3269 nt | ||
| Genomic | GenBank:CR848705 (1) | 259070 nt | ||
| Polypeptide | UniProtKB:Q9PVF7 (1) | 729 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Carver, J.J., Amato, C.M., Yao, H., Zhu, Y. (2024) Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish. Biology of reproduction. 111(5):1107-1128
- Boutillon, A., Escot, S., Elouin, A., Jahn, D., González-Tirado, S., Starruß, J., Brusch, L., David, N.B. (2022) Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Developmental Cell. 57(12):1529-1544.e5
- Cronan, M.R., Hughes, E.J., Brewer, W.J., Viswanathan, G., Hunt, E.G., Singh, B., Mehra, S., Oehlers, S.H., Gregory, S.G., Kaushal, D., Tobin, D.M. (2021) A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell. 184(7):1757-1774.e14
- Espenschied, S.T., Cronan, M.R., Matty, M.A., Mueller, O., Redinbo, M.R., Tobin, D.M., Rawls, J.F. (2019) Epithelial delamination is protective during pharmaceutical-induced enteropathy. Proceedings of the National Academy of Sciences of the United States of America. 116(34):16961-16970
- Jiang, N., Rasmussen, J.P., Clanton, J.A., Rosenberg, M.F., Luedke, K.P., Cronan, M.R., Parker, E.D., Kim, H.J., Vaughan, J.C., Sagasti, A., Parrish, J.Z. (2019) A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. eLIFE. 8:
- Cronan, M.R., Matty, M.A., Rosenberg, A.F., Blanc, L., Pyle, C.J., Espenschied, S.T., Rawls, J.F., Dartois, V., Tobin, D.M. (2018) An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas. Nature Methods. 15:1098-1107
- Dasgupta, A., Merkel, M., Clark, M.J., Jacob, A.E., Dawson, J.E., Manning, M.L., Amack, J.D. (2018) Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle. eLIFE. 7
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cronan, M.R., Beerman, R.W., Rosenberg, A.F., Saelens, J.W., Johnson, M.G., Oehlers, S.H., Sisk, D.M., Jurcic Smith, K.L., Medvitz, N.A., Miller, S.E., Trinh, L.A., Fraser, S.E., Madden, J.F., Turner, J., Stout, J.E., Lee, S., Tobin, D.M. (2016) Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 45:861-876
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