Gene
tcf7l2
- ID
- ZDB-GENE-991110-8
- Name
- transcription factor 7 like 2
- Symbol
- tcf7l2 Nomenclature History
- Previous Names
-
- tcf4
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Involved in digestive system development. Acts upstream of or within several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Located in nucleus. Is expressed in several structures, including anterior neural plate; brain; digestive system; gonad; and sensory system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb316 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| la012186Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018208Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018209Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa103 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2624 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22132 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35327 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35328 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| u754 | Allele with one point mutation | Acceptor Splice Site of Exon 6 | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tcf7l2 | O'Hare et al., 2016 | |
| CRISPR2-tcf7l2 | (2) | |
| CRISPR3-tcf7l2 | Brożko et al., 2022 | |
| MO1-tcf7l2 | N/A | (2) |
| MO2-tcf7l2 | N/A | (4) |
| MO3-tcf7l2 | N/A | Mahmoudi et al., 2010 |
| MO4-tcf7l2 | N/A | (2) |
| MO5-tcf7l2 | N/A | O'Hare et al., 2016 |
| MO6-tcf7l2 | N/A | Young et al., 2019 |
| MO7-tcf7l2 | N/A | Young et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, type 2, susceptibility to} | 125853 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| type 2 diabetes mellitus | tcf7l2zf55/zf55 | standard conditions | Facchinello et al., 2017 |
| type 2 diabetes mellitus | tcf7l2zf55/+ | standard conditions | Facchinello et al., 2017 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR013558 | CTNNB1 binding, N-teminal |
| Family | IPR024940 | Transcription factor TCF/LEF |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor TCF/LEF |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q71G54 | InterPro | 477 | |||||
| UniProtKB:A0A8M1P7C7 | InterPro | 477 | |||||
| UniProtKB:A0AB32TXS6 | InterPro | 613 | |||||
| UniProtKB:A0AB32TXT4 | InterPro | 490 | |||||
| UniProtKB:A0AB32TXT5 | InterPro | 615 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tcf7l2-201
(1)
|
Ensembl | 2,139 nt | ||
| mRNA |
tcf7l2-202
(1)
|
Ensembl | 2,022 nt | ||
| mRNA |
tcf7l2-203
(1)
|
Ensembl | 2,078 nt | ||
| mRNA |
tcf7l2-204
(1)
|
Ensembl | 6,756 nt | ||
| mRNA |
tcf7l2-205
(1)
|
Ensembl | 1,986 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tcf7l2 | monoclonal | IgG1 | Mouse |
|
Biomol GmbH
|
2 | |
| Ab2-tcf7l2 | monoclonal | IgG | Rabbit |
|
Millipore
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(TETRE:Hsa.CTNNB1-2A-tcf7l2) |
|
| 1 | Yao et al., 2018 | |
| Tg(UAS:Hsa.CTNNB1_ABC-tcf7l2) |
|
| 1 | Fei et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-13L15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-41E15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-46I8 | ZFIN Curated Data | |
| Encodes | EST | cegs350 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:195358 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131259 (1) | 4199 nt | ||
| Genomic | GenBank:CR456684 (2) | 262809 nt | ||
| Polypeptide | UniProtKB:A0AB32U028 (1) | 635 aa |
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Park, J.W., Choi, T.I., Kim, T.Y., Lee, Y.R., Don, D.W., George-Abraham, J.K., Robak, L.A., Trandafir, C.C., Liu, P., Rosenfeld, J.A., Kim, T.H., Petit, F., Kim, Y.M., Cheon, C.K., Lee, Y., Kim, C.H. (2024) RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model. Journal of genetics and genomics = Yi chuan xue bao. 51(12):1389-1403
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Brożko, N., Baggio, S., Lipiec, M.A., Jankowska, M., Szewczyk, Ł.M., Gabriel, M.O., Chakraborty, C., Ferran, J.L., Wiśniewska, M.B. (2022) Genoarchitecture of the Early Postmitotic Pretectum and the Role of Wnt Signaling in Shaping Pretectal Neurochemical Anatomy in Zebrafish. Frontiers in Neuroanatomy. 16:838567
- Choi, J.H., Duboue, E.R., Macurak, M., Chanchu, J.M., Halpern, M.E. (2021) Specialized neurons in the right habenula mediate response to aversive olfactory cues. eLIFE. 10:
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Guglielmi, L., Bühler, A., Moro, E., Argenton, F., Poggi, L., Carl, M. (2020) Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry. Development (Cambridge, England). 147(6):
- Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):
- Fei, F., Wang, L., Sun, S., Lv, K., Yao, Y., Wang, J., Yu, M., Wang, X. (2019) Transgenic Strategies to Generate Heterogeneous Hepatic Cancer Models in Zebrafish. Journal of molecular cell biology. 11(11):1021-1023
- Tang, D., He, Y., Li, W., Li, H. (2019) Wnt/β-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast. Experimental & molecular medicine. 51:58
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