Gene
gfap
- ID
- ZDB-GENE-990914-3
- Name
- glial fibrillary acidic protein
- Symbol
- gfap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament organization and regulation of chaperone-mediated autophagy. Located in cytoplasm and type III intermediate filament. Is expressed in several structures, including anterior neural keel; nervous system; neural tube; neuronal stem cell; and optic vesicle. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 125 figures from 85 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb345 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cig6Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ion44dTg | Transgenic insertion | Intron 8 | Unknown | DNA and CRISPR | |
| sa2123 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20045 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33210 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3702Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alexander disease | Alliance | Alexander disease | 203450 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018039 | Intermediate filament protein, conserved site |
| Domain | IPR006821 | Intermediate filament head, DNA-binding domain |
| Domain | IPR039008 | Intermediate filament, rod domain |
| Family | IPR002957 | Keratin, type I |
| Family | IPR050405 | Intermediate filament structural protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament head, DNA-binding domain | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Intermediate filament structural protein | Keratin, type I |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q58EE9 | InterPro | 444 | |||||
| UniProtKB:F1RAE8 | InterPro | 444 | |||||
| UniProtKB:B2GP50 | InterPro | 444 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gfap | monoclonal | IgG1 | Mouse |
|
Dako North America, Inc.
Abcam plc MP Biomedicals |
4 | |
| zrf-1 | monoclonal | IgG1 | Mouse |
|
Zebrafish International Resource Center (ZIRC)
(
order this
)
|
141 | |
| Ab21-gfap | polyclonal | IgG | Rabbit |
|
NSJ Bioreagents
|
2 | |
| Ab2-gfap | polyclonal | Rabbit |
|
Dako North America, Inc.
|
47 | ||
| Ab4-gfap | polyclonal | Rabbit |
|
6 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gfap:EGFP) |
|
| 1 | (43) | |
| Tg(gfap:GFP) |
|
| 3 | (188) | |
| Et(gfap:EGFP) |
|
| 1 | (3) | |
| Tg1(gfap:GAL4) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(2.3gfap:GFP) |
|
| 1 | (3) | |
| Tg2(gfap:EGFP) |
|
| 1 | Gao et al., 2018 | |
| Tg2(gfap:GAL4) |
|
| 1 | (3) | |
| Tg2(gfap:GAL4FF) |
|
| 1 | Frøyset et al., 2018 | |
| Tg2(gfap:mCherry) |
|
| 1 | Ai et al., 2020 | |
| Tg2(gfap:NLS-mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-15N1 | ZFIN Curated Data | |
| Contains | SNP | rs3727711 | ZFIN Curated Data | |
| Encodes | EST | af506734 | ||
| Encodes | EST | cb345 | Thisse et al., 2001 | |
| Encodes | EST | fb34h11 | ZFIN Curated Data | |
| Encodes | EST | fk42c12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110485 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191386 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131373 (1) | 2570 nt | ||
| Genomic | GenBank:BX324157 (1) | 272769 nt | ||
| Polypeptide | UniProtKB:B2GP50 (1) | 444 aa |
- Eghan, K., Lee, S., Yoo, D., Kim, W.K. (2025) 2-Ethylhexanol induces autism-like neurobehavior and neurodevelopmental disorders in zebrafish. Journal of hazardous materials. 488:137469137469
- Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., Xue, C. (2025) Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos. Food research international (Ottawa, Ont.). 200:115502115502
- Mizoguchi, T., Maki, A., Nakase, Y., Okita, M., Minami, Y., Fukunaga, M., Itoh, M. (2025) Neurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology. Brain research bulletin. :111225111225
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- Gence, L., Morello, E., Rastegar, S., Apalama, M.L., Meilhac, O., Bascands, J.L., Diotel, N. (2024) Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis. The European journal of neuroscience. 61(1):e16586
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
- Ma, J., Zhang, W., Rahimialiabadi, S., Ganesh, N.U., Sun, Z., Parvez, S., Peterson, R.T., Yeh, J.J. (2024) Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase. Biology Open. 13(9):
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