Gene
ahr2
- ID
- ZDB-GENE-990714-16
- Name
- aryl hydrocarbon receptor 2
- Symbol
- ahr2 Nomenclature History
- Previous Names
-
- ahrb
- AHR1b (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables nuclear receptor activity and sequence-specific DNA binding activity. Contributes to DNA binding activity. Acts upstream of or within several processes, including fin development; ovarian follicle development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including blood vessel; fin; mandibular arch skeleton; nervous system; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hu3335 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
ihb650 | Allele with one deletion | Unknown | Unknown | CRISPR | |
ihb653 | Allele with one deletion | Unknown | Unknown | not specified | |
la014154Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022159Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022161Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022162Tg | Transgenic insertion | Unknown | Unknown | DNA | |
osu1 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
sa13202 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18313 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ahr2 | (4) | |
CRISPR2-ahr2 | (2) | |
CRISPR3-ahr2 | (2) | |
CRISPR4-ahr2 | Zebrafish Nomenclature Committee | |
CRISPR5-ahr2 | Chen et al., 2024 | |
CRISPR6-ahr2 | Chen et al., 2024 | |
CRISPR7-ahr2 | Chen et al., 2024 | |
MO1-ahr2 | N/A | (55) |
MO2-ahr2 | N/A | Bugel et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q9YGV3 | InterPro | 1027 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(UAS:caahr2-2A-tRFP,cryaa:EGFP) |
| 1 | Martin et al., 2022 | ||
Tg(Xla.Eef1a1:dnahr2-MYC) |
|
| 3 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-74I2 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194789 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131264 (1) | 7126 nt | ||
Genomic | GenBank:BX908726 (2) | 180599 nt | ||
Polypeptide | UniProtKB:Q9YGV3 (1) | 1027 aa |
No data available
- Erradhouani, C., Piccini, B., Maillot-Marechal, E., Aït-Aïssa, S., Balaguer, P., Coumoul, X., Brion, F. (2025) New insights into the regulation of cyp3a65 expression in transgenic tg(cyp3a65:GFP) zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 279:107250107250
- Valderrama, B., Daly, I., Gunnigle, E., O'Riordan, K.J., Chichlowski, M., Banerjee, S., Skowronski, A.A., Pandey, N., Cryan, J.F., Clarke, G., Nagpal, J. (2025) From in silico screening to in vivo validation in zebrafish - a framework for reeling in the right psychobiotics. Food & function. :
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Disner, G.R., Fernandes, T.A.M., Nishiyama-Jr, M.Y., Lima, C., Wincent, E., Lopes-Ferreira, M. (2024) TnP and AHR-CYP1A1 Signaling Crosstalk in an Injury-Induced Zebrafish Inflammation Model. Pharmaceuticals (Basel, Switzerland). 17(9):
- Chen, J., Zhang, M., Zou, H., Aniagu, S., Jiang, Y., Chen, T. (2023) PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development. Toxicology. 487:153466
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Martin, N.R., Patel, R., Kossack, M.E., Tian, L., Camarillo, M.A., Cintrón-Rivera, L.G., Gawdzik, J.C., Yue, M.S., Nwagugo, F.O., Elemans, L.M.H., Plavicki, J.S. (2022) Proper modulation of AHR signaling is necessary for establishing neural connectivity and oligodendrocyte precursor cell development in the embryonic zebrafish brain. Frontiers in molecular neuroscience. 15:10323021032302
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344
- Navarrete, J., Wilson, P., Allsing, N., Gordon, C., Margolis, R., Schwartz, A.V., Cho, C., Rogowski, B., Topps, J., George, U.Z., Sant, K.E. (2021) The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 235:105815
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