Gene
dnmt1
- ID
- ZDB-GENE-990714-15
- Name
- DNA (cytosine-5-)-methyltransferase 1
- Symbol
- dnmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates. Acts upstream of or within several processes, including camera-type eye development; digestive system development; and hemopoiesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb983 (12 images)
- cb1075 (16 images)
- IMAGE:7140056 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
pd1093 | Allele with one point mutation | Unknown | Unknown | ENU | |
rj794 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
s872 | Allele with one MNV | Unknown | Unknown | ENU | |
s904 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa16282 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa20150 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40171 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40172 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40173 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa40174 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant cerebellar ataxia, deafness and narcolepsy | Alliance | Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant | 604121 |
hereditary sensory neuropathy type 1E | Alliance | Neuropathy, hereditary sensory, type IE | 614116 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR018117 | DNA methylase, C-5 cytosine-specific, active site |
Conserved_site | IPR031303 | DNA methylase, C-5 cytosine-specific, conserved site |
Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
Domain | IPR002857 | Zinc finger, CXXC-type |
Domain | IPR010506 | DMAP1-binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | C-5 cytosine methyltransferase | DMAP1-binding domain | DNA Cytosine-5 Methyltransferase | DNA (cytosine-5)-methyltransferase 1-like | DNA (cytosine-5)-methyltransferase 1, replication foci domain | DNA methylase, C-5 cytosine-specific, active site | DNA methylase, C-5 cytosine-specific, conserved site | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Zinc finger, CXXC-type |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6YUX4 | InterPro | 1505 | |||||||||||
UniProtKB:F1RCN0 | InterPro | 1500 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-dnmt1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
9 |
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Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(TRE3G:dnmt1-2A-GFP) |
| 1 | Ma et al., 2023 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-160J1 | ZFIN Curated Data | |
Encodes | EST | cb983 | Thisse et al., 2001 | |
Encodes | EST | cb1075 | Thisse et al., 2001 | |
Encodes | EST | fb05h01 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7140056 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:66111 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195320 | ZFIN Curated Data | |
Encodes | cDNA | MGC:195321 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131189 (1) | 4935 nt | ||
Genomic | GenBank:CU571160 (2) | 81776 nt | ||
Polypeptide | UniProtKB:A0A8M6YUX4 (1) | 1505 aa |
- Cai, H., Zheng, N., Tang, C., Zhang, Y., Zuo, Z., He, C. (2024) Tributyltin causes generational neurodevelopmental toxicity and the protective effect of folic acid in zebrafish. Journal of environmental sciences (China). 137:615625615-625
- Faillace, M.P., Ortiz, J., Rocco, L., Bernabeu, R. (2024) Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish. Molecular neurobiology. 61(9):6245-6263
- Gupta, S., Hui, S.P. (2024) Epigenetic Cross-Talk Between Sirt1 and Dnmt1 Promotes Axonal Regeneration After Spinal Cord Injury in Zebrafish. Molecular neurobiology. :
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Levic, D.S., Niedzwiecki, D., Kandakatla, A., Karlovich, N.S., Juneja, A., Park, J., Stolarchuk, C., Adams, S., Willer, J.R., Schaner, M.R., Lian, G., Beasley, C., Marjoram, L., Flynn, A.D., Valentine, J.F., Onken, J.E., Sheikh, S.Z., Davis, E.E., Evason, K.J., Garman, K.S., Bagnat, M. (2024) TNF Promoter Hypomethylation Is Associated With Mucosal Inflammation in IBD and Anti-TNF Response. Gastro hep advances. 3:888898888-898
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Salazar, M., Joly, S., Anglada-Escudé, G., Ribas, L. (2024) Epigenetic and physiological alterations in zebrafish subjected to hypergravity. PLoS One. 19:e0300310e0300310
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178
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