Gene

cntn2

ID
ZDB-GENE-990630-12
Name
contactin 2
Symbol
cntn2 Nomenclature History
Previous Names
  • si:dz37k09.2
  • tag1
  • transiently expressed axonal glycoprotein
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within nervous system development and positive regulation of axon extension. Predicted to be active in axon and plasma membrane. Is expressed in cardiovascular system; nervous system; and trigeminal placode. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 5. Orthologous to human CNTN2 (contactin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
nub12Allele with one deletionExon 6UnknownCRISPR
sa9412Allele with one point mutationUnknownPremature StopENU
sa12173Allele with one point mutationUnknownPremature StopENU
sa19006Allele with one point mutationUnknownPremature StopENU
sa21903Allele with one point mutationUnknownPremature StopENU
sa35078Allele with one point mutationUnknownPremature StopENU
sa41829Allele with one point mutationUnknownPremature StopENU
sa41830Allele with one point mutationUnknownPremature StopENU
sa41831Allele with one point mutationUnknownPremature StopENU
zou20Allele with one delinsExon 4Premature StopCRISPR
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Sequence Targeting Reagents
1 - 7 of 7
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Human Disease
Associated With cntn2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial adult myoclonic epilepsy 5 Alliance Epilepsy, early-onset, 5, with or without developmental delay 615400
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Associated With cntn2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
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Domain Details Per Protein
Protein Additional Resources Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin domain subtype Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype 2
UniProtKB:Q9W675 InterPro 1040
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cntn2-201 (1) Ensembl 2,781 nt
mRNA cntn2-202 (1) Ensembl 3,123 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cntn2 monoclonal Mouse
  • IHC
  • WB
7
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-73I11ZFIN Curated Data
Contained inPACBUSM1-37K09ZFIN Curated Data
EncodescDNAcssl:d826Bushell et al., 2007
EncodescDNAMGC:193851ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCNTN21
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseCntn21
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 39
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