Gene
cntn2
- ID
- ZDB-GENE-990630-12
- Name
- contactin 2
- Symbol
- cntn2 Nomenclature History
- Previous Names
-
- si:dz37k09.2
- tag1
- transiently expressed axonal glycoprotein
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within nervous system development and positive regulation of axon extension. Predicted to be active in axon and plasma membrane. Is expressed in cardiovascular system; nervous system; and trigeminal placode. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 5. Orthologous to human CNTN2 (contactin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d826 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
nub12 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
sa9412 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12173 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19006 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21903 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa35078 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41829 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41830 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41831 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zou20 | Allele with one delins | Exon 4 | Premature Stop | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-cntn2 | (2) | |
CRISPR2-cntn2 | Gurung et al., 2018 | |
CRISPR3-cntn2 | Spead et al., 2021 | |
CRISPR4-cntn2 | Spead et al., 2021 | |
MO1-cntn2 | N/A | (5) |
MO2-cntn2 | N/A | Liu et al., 2005 |
MO3-cntn2 | N/A | Lin et al., 2012 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
familial adult myoclonic epilepsy 5 | Alliance | Epilepsy, early-onset, 5, with or without developmental delay | 615400 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q9W675 | InterPro | 1040 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-73I11 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-37K09 | ZFIN Curated Data | |
Encodes | cDNA | cssl:d826 | Bushell et al., 2007 | |
Encodes | cDNA | MGC:193851 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131446 (1) | 3980 nt | ||
Genomic | GenBank:AL645810 (2) | 86708 nt | ||
Polypeptide | UniProtKB:Q9W675 (1) | 1040 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Zhang, J., Guo, S., Tao, R., Wang, F., Xie, Y., Wang, H., Ding, L., Shen, Y., Zhou, X., Feng, J., Shen, Q. (2023) Neuroprotective effect of plasmalogens on AlCl3-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center. Neuroscience letters. 818:137560
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Spead, O., Weaver, C.J., Moreland, T., Poulain, F.E. (2021) Live imaging of retinotectal mapping reveals topographic map dynamics and a novel role for Contactin-2 in map sharpening. Development (Cambridge, England). 148(22)
- Wang, D., Wang, X., Huang, H., Wang, H. (2021) Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Journal of hazardous materials. 413:125414
- Gurung, S., Asante, E., Hummel, D., Williams, A., Feldman-Schultz, O., Halloran, M.C., Sittaramane, V., Chandrasekhar, A. (2018) Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish. Mechanisms of Development. 152:1-12
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
- Hoffman, E.J., Turner, K.J., Fernandez, J.M., Cifuentes, D., Ghosh, M., Ijaz, S., Jain, R.A., Kubo, F., Bill, B.R., Baier, H., Granato, M., Barresi, M.J., Wilson, S.W., Rihel, J., State, M.W., Giraldez, A.J. (2016) Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 89(4):725-33
- Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
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