Gene
lft1
- ID
- ZDB-GENE-990630-10
- Name
- lefty1
- Symbol
- lft1 Nomenclature History
- Previous Names
-
- antivin
- atv
- cb73 (1)
- ik:tdsubc_2b12
- xx:tdsubc_2b12
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including LEFTY2 (left-right determination factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 155 figures from 107 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb73 (25 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a145 | Allele with one delins | Unknown | Unknown | TALEN | |
| hg6 | Allele with one point mutation | Unknown | Unknown | ENU | |
| hg7 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa15195 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23761 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-lft1 | N/A | (7) |
| MO2-lft1 | N/A | (2) |
| MO3-lft1 | N/A | (4) |
| MO4-lft1 | N/A | (2) |
| MO5-lft1 | N/A | Feldman et al., 2002 |
| MO6-lft1 | N/A | Choi et al., 2007 |
| TALEN1-lft1 | (6) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR003942 | Left- Right determination factor |
| Family | IPR015615 | Transforming growth factor-beta-related |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Left- Right determination factor | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PW55 | InterPro | 358 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-13.5lft1:EGFP) |
|
| 1 | (7) | |
| Tg(UAS:lft1-UTRnanos3) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-8F4 | ZFIN Curated Data | |
| Encodes | EST | cb73 | (3) | |
| Encodes | EST | tdsubc_2b12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130960 (1) | 1381 nt | ||
| Genomic | GenBank:BX470246 (1) | 148286 nt | ||
| Polypeptide | UniProtKB:Q9PW55 (1) | 358 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zhou, W., Cai, W., Li, Y., Gao, L., Liu, X., Liu, S., Lei, J., Zhang, J., Wang, Y., Jiang, Z., Wu, X., Fan, X., Li, F., Zheng, L., Yuan, W. (2025) The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. International Journal of Molecular Sciences. 26:
- Deng, Z., Ran, Q., Chang, W., Li, C., Li, B., Huang, S., Huang, J., Zhang, K., Li, Y., Liu, X., Liang, Y., Guo, Z., Huang, S. (2024) Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis. Frontiers in cell and developmental biology. 12:14297821429782
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Yao, W., Wei, Z., Tian, X., Tan, J., Liu, J. (2024) Gdf11 regulates left-right asymmetry development through TGF-β signal. Cell Proliferation. :e13765e13765
- Ali, R.Q., Meyer-Miner, A., David-Rachel, M., Lee, F.J.H., Wilkins, B.J., Karpen, S.J., Ciruna, B., Ghanekar, A., Kamath, B.M. (2023) Loss of a cilia-associated gene, pkd1l1, causes biliary defects in zebrafish: Implications for Biliary Atresia Splenic Malformation. Disease models & mechanisms. 16(10):
- Čapek, D., Safroshkin, M., Morales-Navarrete, H., Toulany, N., Arutyunov, G., Kurzbach, A., Bihler, J., Hagauer, J., Kick, S., Jones, F., Jordan, B., Müller, P. (2023) EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways. Nature Methods. 20(6):815-823
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Nagorska, A., Zaucker, A., Lambert, F., Inman, A., Toral-Perez, S., Gorodkin, J., Wan, Y., Smutny, M., Sampath, K. (2023) Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function. Development (Cambridge, England). 150(23):
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