Gene
foxb1a
- ID
- ZDB-GENE-990616-47
- Name
- forkhead box B1a
- Symbol
- foxb1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within mammillary body development. Predicted to be located in nucleus. Is expressed in several structures, including blastodisc; central nervous system; mesoderm; neural keel; and presumptive structure. Orthologous to human FOXB1 (forkhead box B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 78 figures from 49 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb114 (48 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018122 | Fork head domain conserved site1 |
Conserved_site | IPR030456 | Fork head domain conserved site 2 |
Domain | IPR001766 | Fork head domain |
Domain | IPR047389 | Forkhead box protein B1/B2, forkhead domain |
Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein B1/B2, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:O73779 | InterPro | 297 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
foxb1a-201
(1)
|
Ensembl | 1,982 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-2C17 | ZFIN Curated Data | |
Encodes | EST | cb114 | Thisse et al., 2001 | |
Encodes | cDNA | MGC:65743 | ZFIN Curated Data | |
Encodes | cDNA | MGC:76827 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131285 (1) | 1933 nt | ||
Genomic | GenBank:CU462819 (2) | 29958 nt | ||
Polypeptide | UniProtKB:O73779 (1) | 297 aa |
- Engel-Pizcueta, C., Hevia, C.F., Voltes, A., Livet, J., Pujades, C. (2024) Her9 controls the stemness properties of hindbrain boundary cells. Development (Cambridge, England). 152(1):
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Ogawa, Y., Shiraki, T., Fukada, Y., Kojima, D. (2021) Foxq2 determines blue cone identity in zebrafish. Science advances. 7:eabi9784
- Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
- Li, W., Wu, Y., Yuan, M., Liu, X. (2020) Fluxapyroxad induces developmental delay in zebrafish (Danio rerio). Chemosphere. 256:127037
- Li, W., Yuan, M., Wu, Y., Liu, X. (2020) Bixafen exposure induces developmental toxicity in zebrafish (Danio rerio) embryos. Environmental research. 189:109923
- Schredelseker, T., Driever, W. (2020) Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos. Frontiers in Neuroanatomy. 14:3
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Tuazon, F.B., Wang, X., Andrade, J.L., Umulis, D., Mullins, M.C. (2020) Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Reports. 32:108039
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