Gene
opn1sw2
- ID
- ZDB-GENE-990604-40
- Name
- opsin 1 (cone pigments), short-wave-sensitive 2
- Symbol
- opn1sw2 Nomenclature History
- Previous Names
-
- SWS2 (1)
- bluops
- zfblue
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Acts upstream of or within detection of visible light and phototaxis. Located in photoreceptor outer segment. Is expressed in several structures, including endocrine system; heart; integument; photoreceptor cell; and visual system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 81 figures from 52 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73033 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-opn1sw2 | Wang et al., 2023 | |
CRISPR2-opn1sw2 | Wang et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Opsin, blue sensitive | Visual pigments (opsins) retinal binding site |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q9W6A8 | InterPro | 354 | ||||||
UniProtKB:A8E5J4 | InterPro | 354 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
opn1sw2-201
(1)
|
Ensembl | 1,413 nt | ||
mRNA |
opn1sw2-202
(1)
|
Ensembl | 888 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-opn1sw2 | polyclonal | Rabbit |
|
48 |
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Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-1.1opn1sw2:EGFP) |
|
| 1 | (2) | |
Tg(-1.7opn1sw2:EGFP) |
|
| 1 | (2) | |
Tg2(opn1sw2:mCherry) |
|
| 1 | (6) | |
Tg(-3.5opn1sw2:EGFP) |
|
| 1 | (18) | |
Tg(-3.5opn1sw2:tetxlc-CFP) |
|
| 1 | (2) | |
Tg(-5.2opn1sw2:EGFP) |
|
| 1 | (3) | |
Tg(opn1sw2:GFP) |
|
| 1 | Noel et al., 2017 | |
Tg(opn1sw2:KALTA4) |
|
| 2 | (3) | |
Tg(opn1sw2:mCherry) |
|
| 1 | (19) | |
Tg(opn1sw2:NfsB-mCherry) |
|
| 1 | Zebrafish Nomenclature Committee |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-13A21 | ||
Contained in | BAC | DKEY-245F22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:73033 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77574 | ZFIN Curated Data | |
Encodes | cDNA | MGC:174476 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131192 (1) | 1413 nt | ||
Genomic | GenBank:AL844847 (1) | 235174 nt | ||
Polypeptide | UniProtKB:A8E5J4 (1) | 354 aa |
No data available
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Yang, H.Z., Zhuo, D., Huang, Z., Luo, G., Liang, S., Fan, Y., Zhao, Y., Lv, X., Qiu, C., Zhang, L., Liu, Y., Sun, T., Chen, X., Li, S.S., Jin, X. (2024) Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function. Investigative ophthalmology & visual science. 65:3131
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Kramer, A.C., Carthage, J., Berry, Y., Gurdziel, K., Cook, T.A., Thummel, R. (2023) A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish. Frontiers in cell and developmental biology. 11:12332691233269
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
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