Gene
gap43
- ID
- ZDB-GENE-990415-87
- Name
- growth associated protein 43
- Symbol
- gap43 Nomenclature History
- Previous Names
-
- cb310 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity and phospholipid binding activity. Acts upstream of or within axon regeneration and tissue regeneration. Predicted to be located in filopodium membrane; growth cone membrane; and synapse. Predicted to be active in cytoplasm; plasma membrane; and postsynaptic density. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human GAP43 (growth associated protein 43).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb310 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | IQ motif, EF-hand binding site | Neuromodulin (GAP-43) | Neuromodulin gap junction N-terminal | Neuromodulin, palmitoylation site | Neuromodulin, phosphorylation site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90462 | InterPro | 194 | |||||
| UniProtKB:A0A8M1P7P8 | InterPro | 194 |
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- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gap43 | monoclonal | IgG2a | Mouse |
|
Sigma-Aldrich
Santa Cruz Biotechnology, Inc. |
5 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(4xen.cpce-E1B:gap43-mScarlet) |
|
| 1 | (2) | |
| Tg(5xUAS:gap43-GFP) |
|
| 1 | (19) | |
| Tg(-7.2sox10:gap43-Eos) |
|
| 1 | Takamiya et al., 2020 | |
| Tg(hsp70l:gap43-MA-ECFP) |
| 1 | Farrar et al., 2018 | ||
| Tg(UAS:gap43-EGFP-2A-Hsa.TP53_R175H) |
| 1 | Haraoka et al., 2022 | ||
| Tg(UAS:gap43-mKOFP2-2A-Hsa.HRAS_G12V) |
| 1 | Haraoka et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | cb310 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:91783 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192992 | ZFIN Curated Data |
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