Gene
tek
- ID
- ZDB-GENE-990415-56
- Name
- TEK tyrosine kinase, endothelial
- Symbol
- tek Nomenclature History
- Previous Names
-
- tie-2
- tie2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within angiogenesis and heart development. Predicted to be located in cytoskeleton and focal adhesion. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in endothelial cell; vasculature; and vertical myoseptum. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns278 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns347 | Allele with one delins | Unknown | Unknown | CRISPR | |
| bns399 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns400 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns401 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hu1667 | Allele with one point mutation | Unknown | Premature Stop | not specified |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple cutaneous and mucosal venous malformations | Alliance | Venous malformations, multiple cutaneous and mucosal | 600195 |
| Glaucoma 3, primary congenital, E | 617272 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PX37 | InterPro | 997 | ||||||||||||||||
| UniProtKB:O73791 | InterPro | 1116 | ||||||||||||||||
| UniProtKB:A0A8M3ARU2 | InterPro | 1117 | ||||||||||||||||
| UniProtKB:A0AB32TQJ5 | InterPro | 1065 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tek | monoclonal | IgG | Mouse |
|
R&D Systems
|
3 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-87D21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195221 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131461 (1) | 3601 nt | ||
| Genomic | GenBank:CU855580 (2) | 50040 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARU2 (1) | 1117 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Pham, V.C., Rödel, C.J., Valentino, M., Malinverno, M., Paolini, A., Münch, J., Pasquier, C., Onyeogaziri, F.C., Lazovic, B., Girard, R., Koskimäki, J., Hußmann, M., Keith, B., Jachimowicz, D., Kohl, F., Hagelkruys, A., Penninger, J.M., Schulte-Merker, S., Awad, I.A., Hicks, R., Magnusson, P.U., Faurobert, E., Pagani, M., Abdelilah-Seyfried, S. (2024) Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Molecular Medicine. 16(11):2827-2855
- He, Y., Kam, H., Wu, X., Chen, Q., Lee, S.M.Y. (2023) Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption. Chinese Medicine. 18:108108
- Hußmann, M., Schulte, D., Weischer, S., Carlantoni, C., Nakajima, H., Mochizuki, N., Stainier, D.Y.R., Zobel, T., Koch, M., Schulte-Merker, S. (2023) Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. eLIFE. 12:
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Bell, L.M., Holm, A., Matysiak, U., Driever, W., Rößler, J., Schanze, D., Wieland, I., Niemeyer, C.M., Zenker, M., Kapp, F.G. (2021) Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos. Human molecular genetics. 31(1):10-17
- Luo, H., Zhang, Y., Deng, Y., Li, L., Sheng, Z., Yu, Y., Lin, Y., Chen, X., Feng, P. (2021) Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Frontiers in cell and developmental biology. 9:728821
- Matrone, G., Jung, S.Y., Choi, J.M., Jain, A., Leung, H.E., Rajapakshe, K., Coarfa, C., Rodor, J., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nature communications. 12:6282
- Rosello, M., Vougny, J., Czarny, F., Mione, M.C., Concordet, J.P., Albadri, S., Del Bene, F. (2021) Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. eLIFE. 10:
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