Gene
cyp19a1a
- ID
- ZDB-GENE-990415-43
- Name
- cytochrome P450, family 19, subfamily A, polypeptide 1a
- Symbol
- cyp19a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable aromatase activity. Acts upstream of with a positive effect on ovarian follicle development. Acts upstream of or within several processes, including primary sex determination, germ-line; regulation of estrogen biosynthetic process; and response to estradiol. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including endocrine system; eye; female organism; male organism; and reproductive system. Used to study disorder of sexual development. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 93 figures from 66 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb158 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb159 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| uc38 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| uc43 | Allele with one delins | Unknown | Frameshift, Premature Stop | TALEN | |
| umo5 | Allele with one deletion | Unknown | Unknown | TALEN | |
| umo6 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| umo7 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf1031 | Allele with one deletion | Exon 3 | Frameshift | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyp19a1a | (4) | |
| CRISPR2-cyp19a1a | (2) | |
| CRISPR3-cyp19a1a | Liang et al., 2023 | |
| MO1-cyp19a1a | N/A | Chen et al., 2017 |
| MO2-cyp19a1a | N/A | Ulhaq et al., 2018 |
| TALEN1-cyp19a1a | (2) | |
| TALEN2-cyp19a1a | (7) | |
| TALEN3-cyp19a1a | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aromatase deficiency | 613546 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| disorder of sexual development | cyp19a1azf1031/zf1031 (AB) | standard conditions | Yin et al., 2017 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 Monooxygenases | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:O42145 | InterPro | 509 | |||||
| UniProtKB:Q1LV36 | InterPro | 517 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp19a1a-201
(1)
|
Ensembl | 1,862 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB2-cyp19a1a | polyclonal | Rabbit |
|
1 | |||
| Ab1-cyp19a1a | polyclonal | IgG | Rabbit |
|
AnaSpec
|
4 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cyp19a1a:EGFP) |
|
| 1 | (3) | |
| Tg(cyp19a1a:EGFP,crybb1:ECFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-165A16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136541 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194465 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194471 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131154 (1) | 1863 nt | ||
| Genomic | GenBank:BX908722 (2) | 166917 nt | ||
| Polypeptide | UniProtKB:Q1LV36 (1) | 517 aa |
- Shi, C., Zhang, Y., Lu, Y., Lou, Q., Shang, G., Peng, X., Dai, X., Jin, X., He, J., Zhai, G., Yin, Z. (2025) Insights into the role of Fsh signaling in ovarian differentiation of chorionic gonadotropin α ( cgα)-deficient zebrafish. Zoological research. 46:695708695-708
- Wang, Y., Xu, G., Li, H., Gao, J., Du, X., Jiang, W., Ji, G., Liu, Z. (2025) Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish. Marine life science & technology. 7:256270256-270
- Wu, K., Yue, Y., Zhou, L., Zhang, Z., Shan, H., He, H., Ge, W. (2025) Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis. Communications biology. 8:371371
- Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
- Ruan, Y., Li, X., Zhai, G., Lou, Q., Jin, X., He, J., Yin, Z. (2024) Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in Zebrafish. International Journal of Molecular Sciences. 25(3):
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Wang, M., Luo, J., Dai, L., Feng, M., Cao, X., Zhang, J., Wan, Y., Yang, X., Wang, Y. (2024) Foxp2 deficiency impairs reproduction by modulating the hypothalamic-pituitary-gonadal axis in zebrafish. Biology of reproduction. 110(5):908-923
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Liang, F., Dong, Z., Ye, J., Hu, W., Bhandari, R.K., Mai, K., Wang, X. (2023) In vivo DNA methylation editing in zebrafish. Epigenetics. 18:21923262192326
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
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